Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Cancer gene MYC shown to activate gene involved in metastasis

13.09.2005


Study points to importance of pathway in cancer progression



The cancer gene MYC is among the most commonly overexpressed oncogenes in human cancers. Most human cancers demonstrate high levels of MYC or its biological partners, including those of the breast, ovaries, lung, prostate, and skin, as well as leukemias and lymphomas. MYC is a regulator of other genes--a transcription factor--and scientists have been working for more than two decades to identify its target genes in order to understand how MYC causes so many cancers.

Now, scientists at The Wistar Institute have shown that MYC activates a gene called MTA1, which has been demonstrated by other researchers to regulate metastasis in a variety of cancers. While researchers have been exploring the possibility of blocking MTA1 to prevent metastasis, it was not previously known how MTA1 becomes activated in the first place. The study adds to the emerging picture of MYC’s role in cancer development and progression and identifies the pathway linking MYC and MTA1 as an area for further exploration into the genetics of metastasis. The study appears in Proceedings of the National Academy of Sciences and is available in the journal’s online "Early Edition."


"We and others have been working to understand what genes MYC turns on to cause malignant transformation," says Wistar associate professor Steven B. McMahon, Ph.D., senior author of the study. "Understanding metastasis is critical because patients rarely die of primary tumors--metastasis usually causes cancer deaths. Now, we have linked the well-known oncogene MYC to this target gene, MTA1, a key regulator of metastasis. Most importantly, if we block MYC’s ability to turn on MTA1, we block tumor formation. This is critical because it identifies a point in the metastasis pathway that can be targeted therapeutically."

Like the MYC cancer gene, MTA1 has been shown to play a role in a wide range of cancers, including breast and lung cancers and lymphomas. With the help of Wistar’s genomics facility headed by associate professor Louise C. Showe, Ph.D., McMahon and his colleagues sifted through nearly 10,000 genes before identifying MTA1 as a MYC target.

Among the pressing issues still to be resolved is understanding precisely why MYC’s activation of MTA1 leads to metastasis. In spite of the work still to be done, the first generation of drugs that inhibit MTA1 and its partners is already being developed, and McMahon’s study may inform this work. McMahon’s laboratory at Wistar continues to study other target genes of MYC in order to elucidate more fully how this oncogene acts in such a wide range of cancers.

Marion Wyce | EurekAlert!
Further information:
http://www.wistar.org

More articles from Studies and Analyses:

nachricht Real-time feedback helps save energy and water
08.02.2017 | Otto-Friedrich-Universität Bamberg

nachricht The Great Unknown: Risk-Taking Behavior in Adolescents
19.01.2017 | Max-Planck-Institut für Bildungsforschung

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Microhotplates for a smart gas sensor

22.02.2017 | Power and Electrical Engineering

Scientists unlock ability to generate new sensory hair cells

22.02.2017 | Life Sciences

Prediction: More gas-giants will be found orbiting Sun-like stars

22.02.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>