Clioquinol, an antibiotic that was banned for internal use in the United States in 1971 but is still used in topical applications, appears to block the genetic action of Huntingtons disease in mice and in cell culture, according to a study reported by San Francisco VA Medical Center (SFVAMC) researchers.
The study, led by principal investigator Stephen M. Massa, MD, PhD, a neurologist at SFVAMC, was reported in the August 16, 2005 issue of Proceedings of the National Academy of Sciences.
Huntingtons disease is a hereditary, degenerative, and ultimately fatal disease of the brain that causes changes in personality, progressive loss of memory and cognitive ability, and a characteristic uncontrolled jerking motion known as Huntingtons chorea. There is no known cure or effective treatment. A person who carries the mutant Huntingtons gene may pass it on unknowingly because the disease often manifests in early to late middle age after the carriers children have already been born.
Steve Tokar | EurekAlert!
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