Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New anti-thrombotic therapy effective, safer for patients

05.09.2005


World’s largest study on acute coronary syndromes



A Canadian-led study involving researchers from 41 countries has demonstrated in the world’s largest study of acute coronary syndromes (ACS) that a new anti-thrombotic therapy is safer and as effective as the traditional therapy used in preventing heart attacks, death and ischemia in people with serious heart conditions.

The OASIS-5/MICHELANGELO study, presented today at the European Society of Cardiology meeting in Stockholm, Sweden, showed that fondaparinux, a new anti-thrombotic therapy, was as effective as enoxaparin in preventing heart attacks, death and ischemia (reduction in blood supply to the tissues) at nine days after an event but demonstrated a dramatic reduction in major bleeding. The study indicated patients had a lower mortality rate at the one-month mark after an acute coronary event. This finding remained consistent throughout the following six months of follow-up.


These favourable effects resulted in a clear net benefit in favour of fondaparinux throughout the study, said Dr. Salim Yusuf, principal investigator and chair of the international study.

"The study findings demonstrate that fondaparinux is likely the anti-thrombotic drug of choice in patients with acute coronary syndromes who are already receiving aspirin and clopidogrel," said Dr. Yusuf, professor of medicine in the Michael G. DeGroote School of Medicine at McMaster University and director of the Population Health Research Institute, McMaster University and Hamilton Health Sciences in Hamilton, Ontario, Canada. "This is the first study in ACS patients that demonstrates that effective prevention of thrombotic events can be combined with a safer drug profile."

The OASIS-5/MICHELANGELO study was a multi-centre, randomized, double-blind, placebo-controlled trial involving more than 20,000 patients and was conducted at 576 sites in 41 countries. The primary objective was to evaluate the efficacy and safety of fondaparinux, a synthetic drug that acts specifically during the earlier part of the clotting cascade, with enoxaparin, a low molecular weight heparin that is commonly used as an anti-thrombotic therapy.

Previous studies have indicated that patients who experience a major bleed in acute coronary syndromes exhibit a much higher risk of death during the immediate weeks following the event. Anti-thrombotic therapies used in the last two decades have substantially decreased the risk of a heart attack but have also been associated with a significant increase in bleeding risks. Therefore, therapies that maintain the benefits of currently available anti-thrombotic therapies, but have less bleeding, are of great clinical importance, Dr. Yusuf said.

Dr. Shamir R. Mehta, project director of the international study, associate professor of medicine in the Michael G. DeGroote School of Medicine at McMaster University and an interventional cardiologist at Hamilton Health Sciences, remarked: "The fact that the benefits and safety of fondaparinux are observed on top of other effective treatments, such as aspirin, clopidogrel, GP IIb/IIIa inhibitors and revascularization procedures, emphasizes its value in a broad spectrum of patients with acute coronary syndromes."

Dr. Mehta added: "One of the most important findings of the trial was that fondaparinux was associated with a lower overall mortality at six months compared with enoxaparin. This is good news for patients in that doctors now have a therapy that will not only saves lives but is also substantially safer than current treatments."

Professor Keith Fox, professor of cardiology at the University of Edinburgh and co-chair of the study’s operation committee, added: "This study demonstrates that improving the safety of therapy leads to enhanced long-term survival for patients."

Dr. Yusuf noted that previous studies showed that fondaparinux was superior in preventing deep venous thrombosis when compared to enoxaparin. "The current findings extend the beneficial results from the venous side to high-risk individuals with atherothrombosis," he added.

The OASIS-5/MICHELANGELO study was supported by grants from Sanofi-Synthelabo, Organon, and Glaxo-Smith Kline. The OASIS network is led by researchers in the Population Health Research Institute, McMaster University and Hamilton Health Sciences and is an international collaboration of investigators who have completed some of the largest and most influential trials in heart disease that have contributed to enhanced patient care worldwide.

The Canadian Cardiovascular Collaboration Office is located at the Population Health Research Institute, McMaster University and Hamilton Health Sciences and is one of Canada’s leading research institutions. The experts at this institution are recognized internationally for their leading edge research, innovation, and excellence in cardiovascular sciences and thrombosis.

Veronica McGuire | EurekAlert!
Further information:
http://www.mcmaster.ca

More articles from Studies and Analyses:

nachricht Europe’s Demographic Future. Where the Regions Are Heading after a Decade of Crises
10.08.2017 | Berlin-Institut für Bevölkerung und Entwicklung

nachricht Scientists reveal source of human heartbeat in 3-D
07.08.2017 | University of Manchester

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fizzy soda water could be key to clean manufacture of flat wonder material: Graphene

Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.

As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

A Map of the Cell’s Power Station

18.08.2017 | Life Sciences

Engineering team images tiny quasicrystals as they form

18.08.2017 | Physics and Astronomy

Researchers printed graphene-like materials with inkjet

18.08.2017 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>