Low doses of the active form of vitamin D and non-steroidal anti-inflammatory drugs, taken in combination, have been shown to act as a powerful one-two punch that knocks down the growth of prostate cancer cells.
In a study published in the journal "Cancer Research", scientists from Stanford University discovered that the amount of both -- activated vitamin D, or calcitriol, and the NSAIDs -- could be reduced by half to one-tenth the dosage to thwart prostate cancer cell growth in cell lines and primary tissue cultures.
If work in animal models and human trials confirm the findings, the drug combination may help to keep the NSAID family of drugs among the pharmaceutical choices for the prevention and treatment of cancer. This list includes ibuprofen, indomethacin and naproxen, in addition to other so-called COX-2 inhibitors linked to increased risk for cardiovascular disease, including Vioxx® and Celebrex®.
While the scientists showed that activated vitamin D, calcitriol, works by itself to limit prostate cancer growth, it is equally effective in much smaller doses when used in combination with NSAIDs. Furthermore, calcitriol dramatically reduces the amount of NSAIDs necessary to curb prostate cancer cell growth.
This is particularly important now, in light of recent studies showing that some NSAIDs that are selective for COX-2 targeting, such as rofecoxib (Vioxx®) and celecoxib (Celebrex®), are linked to cardiovascular disease at their prescribed doses.
While their studies provide insight into cellular activities controlled by both calcitriol and the NSAIDs, Feldman and his colleagues remain cautious about advancing their new-found understanding of prostaglandin chemistry into patients.
"We need to verify that vitamin D and NSAIDs work in synergy not just in these cell lines, but also work in the same manner, in humans which have a vastly more complex physiology than simple cells in a culture plate," Feldman said.
Vitamin D is converted in the liver and kidney to the active form called calcitriol, a hormone that has widespread actions in the body. The Feldman laboratory used calcitriol in the experiments reported in the Cancer Research article. Vitamin D in the form available over the counter is useful for protection of bones, but would not achieve the therapeutic levels of calcitriol needed to inhibit cancer cell growth, since the body has mechanisms to limit its activation to calcitriol, Feldman explained.
Russell Vanderboom, Ph.D. | EurekAlert!
WAKE-UP provides new treatment option for stroke patients | International study led by UKE
17.05.2018 | Universitätsklinikum Hamburg-Eppendorf
First form of therapy for childhood dementia CLN2 developed
25.04.2018 | Universitätsklinikum Hamburg-Eppendorf
The more electronics steer, accelerate and brake cars, the more important it is to protect them against cyber-attacks. That is why 15 partners from industry and academia will work together over the next three years on new approaches to IT security in self-driving cars. The joint project goes by the name Security For Connected, Autonomous Cars (SecForCARs) and has funding of €7.2 million from the German Federal Ministry of Education and Research. Infineon is leading the project.
Vehicles already offer diverse communication interfaces and more and more automated functions, such as distance and lane-keeping assist systems. At the same...
A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.
The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...
At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.
At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...
There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?
At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...
So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics
Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...
25.05.2018 | Event News
02.05.2018 | Event News
13.04.2018 | Event News
25.05.2018 | Event News
25.05.2018 | Machine Engineering
25.05.2018 | Life Sciences