Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Mayo researchers explore reasons for complications with kidney failure patients

18.08.2005


Mayo Clinic researchers searching for explanations of high mortality rates among kidney failure patients undergoing hemodialysis are focusing their attention on the use of heparin, a drug used to reduce clotting of the blood.

Their study in the August issue of Mayo Clinic Proceedings is a preliminary look at one aspect affecting the health of patients who undergo hemodialysis. In the study, they found patients who had a higher level of adverse outcomes also had elevated levels of heparin antibodies in their blood. The authors believe this is the first study examining this association.

However, Robert McBane, M.D., a Mayo Clinic cardiovascular disease specialist who led the study, cautions that these results are preliminary.



"These results are thought-provoking and hypothesis-generating, but at this point we need more study," says Dr. McBane. "Patients requiring hemodialysis have a high mortality rate for reasons which are not clear. The search for variables contributing to this mortality rate is of prime importance."

Heparin is an anticoagulant, which is usually used to prevent the formation of blood clots in the blood vessels that can prove harmful.

For patients with end-stage renal disease (kidney failure), hemodialysis is the most common form of therapy. Recent figures show more than 85 percent of the approximately 379,000 patients with the disease were treated this way. In hemodialysis, the patient’s blood is passed through a machine to clean it, similar to what the kidneys might do if the body was functioning normally. Heparin must be used to prevent clotting of the blood in the dialysis machine in order to safely perform hemodialysis. At this time, there are no other widely-used alternatives to heparin. The results of this analysis, if confirmed by others, might stimulate the search for better anticoagulants that can be used in hemodialysis.

The study found that the presence of heparin antibodies in hemodialysis patients was associated with more adverse outcomes compared with hemodialysis patients without detectable antibodies. If the findings are confirmed by others, physicians might test for the presence of these antibodies to determine if a patient might be at an above-average risk for complications.

Co-authors in the study include Lourdes Pena de la Vega, M.D., Randal Miller, Margaret Benda, Diane Grill, Matthew Johnson, and James McCarthy, M.D.

In an editorial in the same issue of Mayo Clinic Proceedings, Donald Arnold, M.D., and John Kelton, M.D., of the Department of Medicine, Michael G. DeGroote School of Medicine at McMaster University in Hamilton, Ontario, Canada, say the study adds to the evidence that the heparin antibodies may be an indicator of problems even if other symptoms aren’t evident. But they also say further study is needed.

John Murphy | EurekAlert!
Further information:
http://www.mayo.edu
http://www.mayoclinicproceedings.com

More articles from Studies and Analyses:

nachricht New study: How does Europe become a leading player for software and IT services?
03.04.2017 | Fraunhofer-Institut für System- und Innovationsforschung (ISI)

nachricht Reusable carbon nanotubes could be the water filter of the future, says RIT study
30.03.2017 | Rochester Institute of Technology

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

Im Focus: Using graphene to create quantum bits

In the race to produce a quantum computer, a number of projects are seeking a way to create quantum bits -- or qubits -- that are stable, meaning they are not much affected by changes in their environment. This normally needs highly nonlinear non-dissipative elements capable of functioning at very low temperatures.

In pursuit of this goal, researchers at EPFL's Laboratory of Photonics and Quantum Measurements LPQM (STI/SB), have investigated a nonlinear graphene-based...

Im Focus: Bacteria harness the lotus effect to protect themselves

Biofilms: Researchers find the causes of water-repelling properties

Dental plaque and the viscous brown slime in drainpipes are two familiar examples of bacterial biofilms. Removing such bacterial depositions from surfaces is...

Im Focus: Hydrogen Bonds Directly Detected for the First Time

For the first time, scientists have succeeded in studying the strength of hydrogen bonds in a single molecule using an atomic force microscope. Researchers from the University of Basel’s Swiss Nanoscience Institute network have reported the results in the journal Science Advances.

Hydrogen is the most common element in the universe and is an integral part of almost all organic compounds. Molecules and sections of macromolecules are...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

Innovation 4.0: Shaping a humane fourth industrial revolution

17.05.2017 | Event News

Media accreditation opens for historic year at European Health Forum Gastein

16.05.2017 | Event News

 
Latest News

New approach to revolutionize the production of molecular hydrogen

22.05.2017 | Materials Sciences

Scientists enlist engineered protein to battle the MERS virus

22.05.2017 | Life Sciences

Experts explain origins of topographic relief on Earth, Mars and Titan

22.05.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>