Penn State College of Medicine researchers have found a signal that could lead to earlier detection and treatment of ovarian cancer.
The Penn State team of scientists led by principal investigator Kathleen M. Mulder, Ph.D., professor of pharmacology, and working in conjunction with a researcher from the Center for Cancer Research, National Cancer Institute in Bethesda, Md., studied "km23," a protein that helps to direct protein traffic in the cell. Mulders team has found that at least 42 percent of ovarian cancer patient tumor tissues have alterations in km23. No similar alterations in km23 were detectable in normal human tissues, suggesting that it may be both a diagnostic indicator for the development of ovarian cancer and a possible target for cancer therapies. "While only close to half of ovarian cancer patients may have defects in km23, our results are still highly significant because there is no clinically useful screening test available for detection of ovarian cancer," said Mulder.
Additional studies are under way to continue the analyses of km23 abnormalities in specimens from women with ovarian cancer, and to determine whether different km23 alterations exist in other solid tumors, such as breast and colon cancer. "The next step is to develop a screening test for early detection of the km23 alterations in the blood of ovarian cancer patients," Mulder said. In addition, studies are under way to develop drugs that would target km23 and override the defects caused by the km23 alterations in the cancer cells. "The plan is to be able to use the screening test to identify those patients who would benefit from the anti-cancer drugs we will be developing using km23 as the target," Mulder said. "In the pharmaceutical industry, this is often referred to as personalized medicine, meaning that each patient can be checked for alterations in specific genes and their treatment targeted for the alterations specific to their cancer."
Sean Young | EurekAlert!
New study: How does Europe become a leading player for software and IT services?
03.04.2017 | Fraunhofer-Institut für System- und Innovationsforschung (ISI)
Reusable carbon nanotubes could be the water filter of the future, says RIT study
30.03.2017 | Rochester Institute of Technology
Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...
In the race to produce a quantum computer, a number of projects are seeking a way to create quantum bits -- or qubits -- that are stable, meaning they are not much affected by changes in their environment. This normally needs highly nonlinear non-dissipative elements capable of functioning at very low temperatures.
In pursuit of this goal, researchers at EPFL's Laboratory of Photonics and Quantum Measurements LPQM (STI/SB), have investigated a nonlinear graphene-based...
Dental plaque and the viscous brown slime in drainpipes are two familiar examples of bacterial biofilms. Removing such bacterial depositions from surfaces is...
For the first time, scientists have succeeded in studying the strength of hydrogen bonds in a single molecule using an atomic force microscope. Researchers from the University of Basel’s Swiss Nanoscience Institute network have reported the results in the journal Science Advances.
Hydrogen is the most common element in the universe and is an integral part of almost all organic compounds. Molecules and sections of macromolecules are...
22.05.2017 | Event News
17.05.2017 | Event News
16.05.2017 | Event News
22.05.2017 | Materials Sciences
22.05.2017 | Life Sciences
22.05.2017 | Physics and Astronomy