Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New advance in prostate cancer management

10.08.2005


Scientists from The Institute of Cancer Research have developed a technique which will markedly help in predicting the behaviour of prostate cancer.



At present, prostate cancer tests – needle biopsies, blood and urine samples - are unable to accurately predict how aggressive the cancer is and whether it is likely to progress, resulting in thousands of men undergoing radical preventative surgery which may be unnecessary.

A study - published online today in the British Journal of Cancer* - describes a simple and highly reliable technique, known as the ’Checkerboard Tissue Microarray (TMA) Method’ which can be carried out on prostate cancer needle biopsies. The Checkerboard TMA Method looks for multiple markers of various genes associated with prostate cancer, including the E2F3 gene. Overexpression of the E2F3 gene, first identified at The Institute of Cancer Research, is a marker of how aggressive the prostate cancer will be.


The new technique will allow the investigation of an enormous untapped resource of clinical specimens obtained at the time of diagnosis of cancer, in order to identify markers of the cancer’s aggressiveness. The technique will be pivotal in developing a test for prostate cancer aggressiveness which may ultimately prevent thousands of men undergoing unnecessary surgery, with its often associated severe side effects including incontinence and impotence.

"This represents a real advance for the future management of prostate cancer," said Professor Colin Cooper, The Grand Charity of Freemasons’ Chair of Molecular Biology at The Institute of Cancer Research. "Eventually we hope to be able to distinguish the tigers - aggressive tumours requiring treatment - from the pussycats - non aggressive tumours which can be monitored for many years without treatment. Ultimately this could prevent thousands of men from having to undergo radical surgery, which can have devastating effects on their day to day lives."

Prostate cancer is now the most common cancer to affect men in the UK. More than 30,000 men in the UK are diagnosed with the disease and almost 10,000 men die from the disease each year.

Professor Peter Rigby, Chief Executive at The Institute of Cancer Research comments:

"This demonstrates the real progress we are making in the field of prostate cancer research. Since discovering the E2F3 gene as a marker of prostate cancer aggressiveness our research team has been committed to developing a test for the gene. The development of this technique is a significant step forward in prostate cancer management and should ultimately improve thousands of men’s lives."

Nadia Ramsey | EurekAlert!
Further information:
http://www.icr.ac.uk

More articles from Studies and Analyses:

nachricht Win-win strategies for climate and food security
02.10.2017 | International Institute for Applied Systems Analysis (IIASA)

nachricht The personality factor: How to foster the sharing of research data
06.09.2017 | ZBW – Leibniz-Informationszentrum Wirtschaft

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

Im Focus: Shrinking the proton again!

Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.

It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

Climate Engineering Conference 2017 Opens in Berlin

10.10.2017 | Event News

 
Latest News

Terahertz spectroscopy goes nano

20.10.2017 | Information Technology

Strange but true: Turning a material upside down can sometimes make it softer

20.10.2017 | Materials Sciences

NRL clarifies valley polarization for electronic and optoelectronic technologies

20.10.2017 | Interdisciplinary Research

VideoLinks
B2B-VideoLinks
More VideoLinks >>>