Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New advance in prostate cancer management

10.08.2005


Scientists from The Institute of Cancer Research have developed a technique which will markedly help in predicting the behaviour of prostate cancer.



At present, prostate cancer tests – needle biopsies, blood and urine samples - are unable to accurately predict how aggressive the cancer is and whether it is likely to progress, resulting in thousands of men undergoing radical preventative surgery which may be unnecessary.

A study - published online today in the British Journal of Cancer* - describes a simple and highly reliable technique, known as the ’Checkerboard Tissue Microarray (TMA) Method’ which can be carried out on prostate cancer needle biopsies. The Checkerboard TMA Method looks for multiple markers of various genes associated with prostate cancer, including the E2F3 gene. Overexpression of the E2F3 gene, first identified at The Institute of Cancer Research, is a marker of how aggressive the prostate cancer will be.


The new technique will allow the investigation of an enormous untapped resource of clinical specimens obtained at the time of diagnosis of cancer, in order to identify markers of the cancer’s aggressiveness. The technique will be pivotal in developing a test for prostate cancer aggressiveness which may ultimately prevent thousands of men undergoing unnecessary surgery, with its often associated severe side effects including incontinence and impotence.

"This represents a real advance for the future management of prostate cancer," said Professor Colin Cooper, The Grand Charity of Freemasons’ Chair of Molecular Biology at The Institute of Cancer Research. "Eventually we hope to be able to distinguish the tigers - aggressive tumours requiring treatment - from the pussycats - non aggressive tumours which can be monitored for many years without treatment. Ultimately this could prevent thousands of men from having to undergo radical surgery, which can have devastating effects on their day to day lives."

Prostate cancer is now the most common cancer to affect men in the UK. More than 30,000 men in the UK are diagnosed with the disease and almost 10,000 men die from the disease each year.

Professor Peter Rigby, Chief Executive at The Institute of Cancer Research comments:

"This demonstrates the real progress we are making in the field of prostate cancer research. Since discovering the E2F3 gene as a marker of prostate cancer aggressiveness our research team has been committed to developing a test for the gene. The development of this technique is a significant step forward in prostate cancer management and should ultimately improve thousands of men’s lives."

Nadia Ramsey | EurekAlert!
Further information:
http://www.icr.ac.uk

More articles from Studies and Analyses:

nachricht Drone vs. truck deliveries: Which create less carbon pollution?
31.05.2017 | University of Washington

nachricht New study: How does Europe become a leading player for software and IT services?
03.04.2017 | Fraunhofer-Institut für System- und Innovationsforschung (ISI)

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can we see monkeys from space? Emerging technologies to map biodiversity

An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.

Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

Im Focus: Scientists develop molecular thermometer for contactless measurement using infrared light

Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine

Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

Quantum thermometer or optical refrigerator?

23.06.2017 | Physics and Astronomy

A 100-year-old physics problem has been solved at EPFL

23.06.2017 | Physics and Astronomy

Equipping form with function

23.06.2017 | Information Technology

VideoLinks
B2B-VideoLinks
More VideoLinks >>>