Actelion Ltd (SWX: ATLN) announced today that a study published in the July edition of the Journal of Neurosurgery suggests that clazosentan can reduce the number and severity of cases of vasospasm following aneurysmal subarachnoid haemorrhage (SAH).1
Vasospasm occurs 5-14 days following SAH and leads to strokes and neurological deficits that cause significant disability to patients and is a major cause of death. As many as 70% of people who have aneurysmal SAH may have arterial narrowing and even with the most advanced surgical and endovascular advances in securing the aneurysm, the outcomes remain poor with up to 30% developing neurological deficits or dying2.
This Phase IIa study with 34 patients demonstrated that patients given the i.v. endothelin receptor antagonist clazosentan continuously for up to 14 days suffered from significantly fewer and less severe cases of vasospasm compared to placebo. Only 40% of patients treated with clazosentan developed cerebral vasospasm, as diagnosed on angiography, compared to 88% of patients treated with placebo (p=0.008).1
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