Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Poly/mono balance important to cholesterol-lowering diet

04.07.2005


In the search for the best fats for a heart healthy diet, trans- and saturated fats have long been recognized as undesirable and those that contain polyunsaturated fatty acids (PUFAs) and mono-unsaturated fatty acids (MUFAs) are preferred -- with no clear benefit demonstrated for higher levels of either the PUFAs or the MUFAs within recommended limits.



Now, a Penn State study provides evidence that the optimum dietary fat isn’t one that contains either more PUFAs or more MUFAs, but one that contains a proper balance of both to control cardiovascular risk factors.

In the Penn State study, detailed in the current issue of the Journal of the American Dietetic Association, two heart healthy oils, a new PUFA-rich sunflower oil (NuSun) and the more MUFA-rich olive oil, were compared in a diet designed to lower blood cholesterol levels.


Dr. Penny Kris Etherton, distinguished professor of nutrition who directed the study, says, "We expected the PUFAs, which are higher in the sunflower oil than the olive oil, to produce a greater reduction in total and LDL cholesterol levels in the study participants -- and they did. The surprise was the fact that the olive oil diet, which is also low in saturated fat, did not lower cholesterol levels compared with the average American diet. Also surprising was that the greater percentage of PUFAs in the NuSun sunflower oil diet did not increase LDL oxidation products that are risk factors for atherosclerosis."

The results are described in the paper, "Balance of Unsaturated Fatty Acids is Important to Cholesterol-Lowering Diet: Comparison of Mid-Oleic Sunflower Oil and Olive Oil on Cardiovascular Disease Risk Factors." The authors are Dr. Amy E. Binkoski, former Penn State doctoral student, Dr. Penny M. Kris-Etherton, distinguished professor of nutritional sciences, Dr. Thomas W. Wilson, assistant professor, University of Massachusetts Lowell, Margaret L. Mountain, dietitian, University of Pittsburgh Medical Center, and Dr. Robert J. Nicolosi, professor and director of the Center for Health and Disease Research, University of Massachusetts Lowell.

The researchers recruited 31 healthy men and women, ages 25 to 64, who had moderately elevated LDL cholesterol. The women’s LDL cholesterol was in the 140 to 188 range and the men’s was between 129 and 177.

The participants each ate three different diets: an olive oil-based diet, a NuSun sunflower oil-based diet or an average American diet. The two oil-based diets limited fat to 30 percent of calories and the average American diet had 34 percent fat calories. The volunteers ate each diet for four weeks, took a two-week break when they ate their usual diet and then moved on to the next diet. Blood samples were taken at the end of each diet period.

Analysis of the participants’ blood samples showed that the NuSun sunflower oil diet significantly reduced total and LDL cholesterol levels compared with the average American diet. No significant differences were observed between the olive oil diet and the average American diet.

The ratios of total cholesterol to HDL cholesterol and LDL to HDL cholesterol were not significantly different among the three diets. Triglyceride levels also were similar among all three diets.

Some previous studies have shown a greater production of oxidation products following consumption of a high PUFA diet compared with a high MUFA diet. However, in this study, while the NuSun sunflower diet did not have a beneficial effect on LDL oxidation, there were no adverse effects despite the increase in PUFAs.

Kris-Etherton says, "Within the context of a moderate fat diet, it is becoming clear that a mixture of unsaturated fatty acids provides the greatest health benefits."

Barbara Hale | EurekAlert!
Further information:
http://www.psu.edu

More articles from Studies and Analyses:

nachricht Rutgers-led innovation could spur faster, cheaper, nano-based manufacturing
14.02.2018 | Rutgers University

nachricht New study from the University of Halle: How climate change alters plant growth
12.01.2018 | Martin-Luther-Universität Halle-Wittenberg

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Developing reliable quantum computers

International research team makes important step on the path to solving certification problems

Quantum computers may one day solve algorithmic problems which even the biggest supercomputers today can’t manage. But how do you test a quantum computer to...

Im Focus: In best circles: First integrated circuit from self-assembled polymer

For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.

In the self-assembly process, the semiconducting polymer arranges itself into an ordered monolayer in a transistor. The transistors are binary switches used...

Im Focus: Demonstration of a single molecule piezoelectric effect

Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale

Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...

Im Focus: Hybrid optics bring color imaging using ultrathin metalenses into focus

For photographers and scientists, lenses are lifesavers. They reflect and refract light, making possible the imaging systems that drive discovery through the microscope and preserve history through cameras.

But today's glass-based lenses are bulky and resist miniaturization. Next-generation technologies, such as ultrathin cameras or tiny microscopes, require...

Im Focus: Stem cell divisions in the adult brain seen for the first time

Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.

The generation of new nerve cells was once thought to taper off at the end of embryonic development. However, recent research has shown that the adult brain...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

2nd International Conference on High Temperature Shape Memory Alloys (HTSMAs)

15.02.2018 | Event News

Aachen DC Grid Summit 2018

13.02.2018 | Event News

How Global Climate Policy Can Learn from the Energy Transition

12.02.2018 | Event News

 
Latest News

Stiffness matters

22.02.2018 | Life Sciences

Magnetic field traces gas and dust swirling around supermassive black hole

22.02.2018 | Physics and Astronomy

First evidence of surprising ocean warming around Galápagos corals

22.02.2018 | Earth Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>