Researchers at Yale School of Medicine have discovered the breast cancer growth regulator sEGFR, which may be a useful tool in monitoring a patients responsiveness to treatment with the drug letrozole.
Published in a recent issue of the American Association of Cancer Researchers journal Cancer Research, the study focused on how decreased concentrations of sEGFR can indicate the effectiveness of letrozole.
In women with postmenopausal breast cancer, the hormone estrogen often stimulates tumor growth. Letrozole, which is currently used in breast cancer therapy, stops the local production of estrogen, therefore reducing tumor growth. To monitor the effectiveness of this drugs reduction in tumor growth, estrogen levels are measured. In postmenopausal women with breast cancer, estrogen can be difficult to measure because the levels are already quite low. The Yale team, led by Nita J. Maihle, professor in the Department of Obstetrics, Gynecology & Reproductive Sciences, discovered sEGFR, another regulator of breast cancer growth that can be used to measure responsiveness to treatment.
Karen N. Peart | EurekAlert!
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