Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Breast cancer growth regulator holds promise for more targeted treatment

27.06.2005


Researchers at Yale School of Medicine have discovered the breast cancer growth regulator sEGFR, which may be a useful tool in monitoring a patient’s responsiveness to treatment with the drug letrozole.



Published in a recent issue of the American Association of Cancer Researcher’s journal Cancer Research, the study focused on how decreased concentrations of sEGFR can indicate the effectiveness of letrozole.

In women with postmenopausal breast cancer, the hormone estrogen often stimulates tumor growth. Letrozole, which is currently used in breast cancer therapy, stops the local production of estrogen, therefore reducing tumor growth. To monitor the effectiveness of this drug’s reduction in tumor growth, estrogen levels are measured. In postmenopausal women with breast cancer, estrogen can be difficult to measure because the levels are already quite low. The Yale team, led by Nita J. Maihle, professor in the Department of Obstetrics, Gynecology & Reproductive Sciences, discovered sEGFR, another regulator of breast cancer growth that can be used to measure responsiveness to treatment.


Maihle and her colleagues collected blood samples from postmenopausal women with metastatic breast cancer before treatment with letrozole and then one month and three months after letrozole therapy. The team measured sEGFR concentrations in these blood samples and found that after one month of letrozole therapy, sEGFR decreased in 73 percent of patients and after three months of letrozole therapy, sEGFR concentrations decreased in 76 percent of patients when compared to pretreatment levels.

"Unfortunately, the number of patients (43) involved in this study was not large enough to evaluate how these changes in sEGFR levels predict a patient’s cancer progression or survival," said Maihle. "Since the FDA recently approved letrozole for the treatment of breast cancer, larger studies are needed to determine its clinical utility."

"Ultimately, we hope to provide the most effective ways to determine who will respond to this new breast cancer therapy," added Maihle, who is also affiliated with Yale Cancer Center.

Other authors on the study included Jacqueline M. Lafky, Andre T. Baron, Elsa M. Cora, David W. Hillman, Vera J. Suman, Edith A. Perez and James N. Ingle.

Karen N. Peart | EurekAlert!
Further information:
http://www.yale.edu

More articles from Studies and Analyses:

nachricht WAKE-UP provides new treatment option for stroke patients | International study led by UKE
17.05.2018 | Universitätsklinikum Hamburg-Eppendorf

nachricht First form of therapy for childhood dementia CLN2 developed
25.04.2018 | Universitätsklinikum Hamburg-Eppendorf

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Powerful IT security for the car of the future – research alliance develops new approaches

The more electronics steer, accelerate and brake cars, the more important it is to protect them against cyber-attacks. That is why 15 partners from industry and academia will work together over the next three years on new approaches to IT security in self-driving cars. The joint project goes by the name Security For Connected, Autonomous Cars (SecForCARs) and has funding of €7.2 million from the German Federal Ministry of Education and Research. Infineon is leading the project.

Vehicles already offer diverse communication interfaces and more and more automated functions, such as distance and lane-keeping assist systems. At the same...

Im Focus: Molecular switch will facilitate the development of pioneering electro-optical devices

A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.

The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

In focus: Climate adapted plants

25.05.2018 | Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

 
Latest News

In focus: Climate adapted plants

25.05.2018 | Event News

Flow probes from the 3D printer

25.05.2018 | Machine Engineering

Less is more? Gene switch for healthy aging found

25.05.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>