Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Researchers report breakthrough against world’s deadliest viruses

06.06.2005


New Ebola, Marburg Vaccines effective in animal models

Scientists from the Public Health Agency of Canada - with assistance from the U.S. Army Medical Research Institute of Infectious Diseases - have developed vaccines against the Ebola and Marburg viruses that have been shown to be effective in non-human primates.

In a study published in this month’s Nature Medicine, Canadian researchers Dr. Heinz Feldmann and Dr. Steven Jones of PHAC’s National Microbiology Laboratory and Dr. Thomas Geisbert of USAMRIID report that the vaccines have proven 100 percent effective in protecting monkeys against infection from these often deadly viruses.



Monkeys are known to develop hemorrhagic fever symptoms that are similar to those observed in humans infected by these viruses. Demonstrating that these vaccines are safe and effective in monkeys is a promising indicator of their real potential for use in humans.

"When you see the tragedies these viruses cause, it’s very frustrating that we can’t do more to help people," said Dr. Feldmann, who (along with Dr. Jones and others from PHAC) has been providing on-site rapid diagnostic support to the current Marburg outbreak in Angola. "It’ll be some time before we can use these vaccines in the field, but it’s satisfying to know that we’re getting closer."

According to Dr. Geisbert, this is the first vaccine system, or platform, that has protected nonhuman primates from both Ebola and Marburg. "In addition, the vaccine targets dendritic cells, which are the same cells that Ebola and Marburg attack," said Dr. Geisbert. "These cells are also important in generating a protective immune response. So the vaccine goes exactly where we want it to go."

The study describes how Canadian researchers developed the vaccines by replacing a surface protein in an animal pathogen, called vesicular stomatitis virus, with a surface protein from either the Ebola or Marburg viruses. Following extensive work, including trials with mice and guinea pigs, the PHAC researchers collaborated with USAMRIID to prove their efficacy in non-human primates.

Canadian Health Minister Ujjal Dosanjh and Dr. Carolyn Bennett, Minister of State (Public Health), praised the work of the scientists in developing the vaccine and providing support to the outbreak in Angola.

"This speaks volumes about the dedication and expertise of these individuals, and also what can be achieved through international collaboration," said Minister Dosanjh. Minister Bennett added that people everywhere could benefit from the vaccine development,"in stopping outbreaks where they originate as well as reducing the risk that these viruses will be used in bioterrorism."

Colonel Erik A. Henchal, commander of USAMRIID, said the study illustrates the benefits of collaborative research to develop medical countermeasures for biodefense.

"Relationships like this contribute to better science and ultimately better protection for military service members and civilians alike."

Caree Vander Linden | EurekAlert!
Further information:
http://ww.us.army.mil

More articles from Studies and Analyses:

nachricht Antarctic Ice Sheet mass loss has increased
14.06.2018 | Technische Universität Dresden

nachricht WAKE-UP provides new treatment option for stroke patients | International study led by UKE
17.05.2018 | Universitätsklinikum Hamburg-Eppendorf

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: AchemAsia 2019 will take place in Shanghai

Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.

Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...

Im Focus: First real-time test of Li-Fi utilization for the industrial Internet of Things

The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.

Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.

Im Focus: Sharp images with flexible fibers

An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.

Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...

Im Focus: Photoexcited graphene puzzle solved

A boost for graphene-based light detectors

Light detection and control lies at the heart of many modern device applications, such as smartphone cameras. Using graphene as a light-sensitive material for...

Im Focus: Water is not the same as water

Water molecules exist in two different forms with almost identical physical properties. For the first time, researchers have succeeded in separating the two forms to show that they can exhibit different chemical reactivities. These results were reported by researchers from the University of Basel and their colleagues in Hamburg in the scientific journal Nature Communications.

From a chemical perspective, water is a molecule in which a single oxygen atom is linked to two hydrogen atoms. It is less well known that water exists in two...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Munich conference on asteroid detection, tracking and defense

13.06.2018 | Event News

2nd International Baltic Earth Conference in Denmark: “The Baltic Sea region in Transition”

08.06.2018 | Event News

ISEKI_Food 2018: Conference with Holistic View of Food Production

05.06.2018 | Event News

 
Latest News

A sprinkle of platinum nanoparticles onto graphene makes brain probes more sensitive

15.06.2018 | Materials Sciences

100 % Organic Farming in Bhutan – a Realistic Target?

15.06.2018 | Ecology, The Environment and Conservation

Perovskite-silicon solar cell research collaboration hits 25.2% efficiency

15.06.2018 | Power and Electrical Engineering

VideoLinks
Science & Research
Overview of more VideoLinks >>>