Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Study shows using expanded critera donors is safe

25.05.2005


Patients who had received livers from hepatitis B virus core antibody (HBcAb) positive (indicates prior exposure to hepatitis B) and/or hepatitis C virus (HCV) positive donors had similar graft and patient survival compared to patients who received HBcAb negative or HCV negative livers, according to a study by the University of Pittsburgh’s Thomas E. Starzl Transplantation Institute. The results of their findings are being presented today at sixth annual American Transplant Congress, the joint scientific meeting of the American Society of Transplant Surgeons and the American Society of Transplantation at the Washington State Convention & Trade Center in Seattle.

To help alleviate the shortage of organs, there has been an increase in the transplantation of livers obtained from extended criteria donors, such as organs from HBcAb positive and HCV positive donors. In the Pitt study, the researchers conducted a seven-year review of liver transplant recipients who received HBV positive and HCV positive organs between 1997 and 2004. The patients were divided into three groups. Group one consisted of 28 patients that received both HBcAb positive and HCV positive livers; the second group consisted of 58 patients that received HBcAb positive livers; and the third group consisted of 34 patients that received HCV positive livers. Patient and graft survival and recurrence of the HBV and HCV infections were compared between the various groups of patients.

Treatment to prevent recurrent HBV infection consisted of hepatitis B immune globulin and/or lamivudine for groups one and two. The mean follow up for all patients was two years and there were no significant differences between recipients of all groups with respect to age, sex and MELD scores – a liver transplant scoring system which estimates a patient’s risk of dying while waiting for the transplant.


Patient and graft survival were the following: Group one, 68 percent and 64 percent respectively; Group two, 76 percent and 65 percent respectively; Group three, 82 percent and 76 percent respectively. Overall, recurrent HBV post-transplantation occurred in four out of 86 patients and no grafts were lost to HBV recurrence. Of those patients who received HCV positive livers, 15 of 62 patients who received HCV positive grafts have died; two deaths were due to HCV graft failure and another two were HCV related. One patient has been re-transplanted for recurrent HCV cirrhosis. While HCV recurrence in groups one and three were universal, the severity of recurrence and response to interferon-based therapy was comparable to HCV patients who received HCV negative livers.

Michael E. de Vera, M.D., assistant professor of surgery at the University of Pittsburgh’s Thomas E. Starzl Transplantation Institute and lead author of the study, concluded based on these research findings that the use of HBV and/or HCV positive livers for organ donation is safe. HBV recurrence is minimal with the use of HBV prophylaxis and HCV recurrence is similar to that of HCV patients who receive HCV negative livers.

"These findings substantiate the practice of transplanting HBcAb positive and/or HCV positive livers. When selected properly for transplantation, these organs are often of good quality, and so long as they are transplanted to the appropriate recipients, long-term results are comparable to patients who receive livers from HBV- or HCV-negative donors. The use of these livers significantly increases the number of organs available for transplantation," according to Amadeo Marcos, M.D., chief, clinical transplantation at the University of Pittsburgh’s Thomas E. Starzl Transplantation Institute.

Maureen McGaffin | EurekAlert!
Further information:
http://www.upmc.edu

More articles from Studies and Analyses:

nachricht The personality factor: How to foster the sharing of research data
06.09.2017 | ZBW – Leibniz-Informationszentrum Wirtschaft

nachricht Europe’s Demographic Future. Where the Regions Are Heading after a Decade of Crises
10.08.2017 | Berlin-Institut für Bevölkerung und Entwicklung

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Ultrafast snapshots of relaxing electrons in solids

Using ultrafast flashes of laser and x-ray radiation, scientists at the Max Planck Institute of Quantum Optics (Garching, Germany) took snapshots of the briefest electron motion inside a solid material to date. The electron motion lasted only 750 billionths of the billionth of a second before it fainted, setting a new record of human capability to capture ultrafast processes inside solids!

When x-rays shine onto solid materials or large molecules, an electron is pushed away from its original place near the nucleus of the atom, leaving a hole...

Im Focus: Quantum Sensors Decipher Magnetic Ordering in a New Semiconducting Material

For the first time, physicists have successfully imaged spiral magnetic ordering in a multiferroic material. These materials are considered highly promising candidates for future data storage media. The researchers were able to prove their findings using unique quantum sensors that were developed at Basel University and that can analyze electromagnetic fields on the nanometer scale. The results – obtained by scientists from the University of Basel’s Department of Physics, the Swiss Nanoscience Institute, the University of Montpellier and several laboratories from University Paris-Saclay – were recently published in the journal Nature.

Multiferroics are materials that simultaneously react to electric and magnetic fields. These two properties are rarely found together, and their combined...

Im Focus: Fast, convenient & standardized: New lab innovation for automated tissue engineering & drug

MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems Holding GmbH about commercial use of a multi-well tissue plate for automated and reliable tissue engineering & drug testing.

MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems...

Im Focus: Silencing bacteria

HZI researchers pave the way for new agents that render hospital pathogens mute

Pathogenic bacteria are becoming resistant to common antibiotics to an ever increasing degree. One of the most difficult germs is Pseudomonas aeruginosa, a...

Im Focus: Artificial Enzymes for Hydrogen Conversion

Scientists from the MPI for Chemical Energy Conversion report in the first issue of the new journal JOULE.

Cell Press has just released the first issue of Joule, a new journal dedicated to sustainable energy research. In this issue James Birrell, Olaf Rüdiger,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

“Lasers in Composites Symposium” in Aachen – from Science to Application

19.09.2017 | Event News

I-ESA 2018 – Call for Papers

12.09.2017 | Event News

EMBO at Basel Life, a new conference on current and emerging life science research

06.09.2017 | Event News

 
Latest News

“Lasers in Composites Symposium” in Aachen – from Science to Application

19.09.2017 | Event News

New quantum phenomena in graphene superlattices

19.09.2017 | Physics and Astronomy

A simple additive to improve film quality

19.09.2017 | Power and Electrical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>