Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Dye to pinpoint diseases and pathogens

19.05.2005


University of Toronto researchers have designed a chemical screening tool that will light up when dangerous pathogens and diseases in air, water and bodily fluids are present.



"This detection technique, which uses DNA to seek out target DNA, could one day be used in clinical care situations to quickly detect diseases such as AIDS and hepatitis," says Professor Ulrich Krull, the AstraZeneca Chair in biotechnology and vice-principal (research) at the University of Toronto at Mississauga. "It could also act to constantly monitor the environment and sound an alarm if harmful agents were to appear."

In a study, outlined in the March issue of Bioorganic & Medicinal Chemistry Letters, Krull and graduate student Xiaofeng Wang used a fluorescent dye attached to probe DNA that binds to specific target DNA sequences, illuminates in the presence of a targeted pathogen or genetic mutation and then sends a detection signal through an optical fibre. By simply adding heat, the dye unbinds and the detection chemistry is ready to test the next sample. The chemical screening system fits onto a microchip and soon could test blood and water samples in a matter of seconds.


Krull says that while commercial development will still be needed to build a portable technology to facilitate this detection strategy, this research provides the basis for a re-usable, quick and compact sample testing system. "The idea here is to have something like a thermometer that will monitor the environment and the body," he says. "But instead of temperature, you are monitoring for DNA fragments indicative of problems that can cause disease and infections. There are very few tests like this that allow for continuous monitoring."

Karen Kelly | EurekAlert!
Further information:
http://www.utoronto.ca

More articles from Studies and Analyses:

nachricht New study from the University of Halle: How climate change alters plant growth
12.01.2018 | Martin-Luther-Universität Halle-Wittenberg

nachricht Disarray in the brain
18.12.2017 | Universität zu Lübeck

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Artificial agent designs quantum experiments

On the way to an intelligent laboratory, physicists from Innsbruck and Vienna present an artificial agent that autonomously designs quantum experiments. In initial experiments, the system has independently (re)discovered experimental techniques that are nowadays standard in modern quantum optical laboratories. This shows how machines could play a more creative role in research in the future.

We carry smartphones in our pockets, the streets are dotted with semi-autonomous cars, but in the research laboratory experiments are still being designed by...

Im Focus: Scientists decipher key principle behind reaction of metalloenzymes

So-called pre-distorted states accelerate photochemical reactions too

What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...

Im Focus: The first precise measurement of a single molecule's effective charge

For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.

Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...

Im Focus: Paradigm shift in Paris: Encouraging an holistic view of laser machining

At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.

No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...

Im Focus: Room-temperature multiferroic thin films and their properties

Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.

Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

10th International Symposium: “Advanced Battery Power – Kraftwerk Batterie” Münster, 10-11 April 2018

08.01.2018 | Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

 
Latest News

Thanks for the memory: NIST takes a deep look at memristors

22.01.2018 | Materials Sciences

Radioactivity from oil and gas wastewater persists in Pennsylvania stream sediments

22.01.2018 | Earth Sciences

Saarland University bioinformaticians compute gene sequences inherited from each parent

22.01.2018 | Life Sciences

VideoLinks Wissenschaft & Forschung
Overview of more VideoLinks >>>