A University of Minnesota study is the first to show that if you eat too much fat, it can go straight to your liver and damage it.
In obese people with nonalcoholic fatty liver disease (NAFLD), fat from the diet ends up "stuck" in the liver, where it doesnt belong. It was known that the livers of NAFLD patients accumulated fat, but its origin was unknown. The new work implicates fat from the diet as one cause of NAFLD and shows that fat buildup in the liver results when the liver loses its ability to manage the various influxes of fat that occur during transitions between the fasted and fed states. Identifying the origins of accumulated fat in the livers of NAFLD patients will be important in preventing and reversing this condition, which can lead to more serious liver trouble. The work will be published May 2 in the Journal of Clinical Investigation.
"This is the first scientific proof of dietary fat stored in the liver in humans," said Elizabeth Parks, an associate professor of human nutrition, who led the study. "In health, its the livers job to store glycogen--a storage form of carbohydrates--not fat." The clear implication is that too much dietary fat leads the liver to fail in its mission as the bodys central shipping and receiving center for fat. No longer does it take in dietary fat, repackage it and send it on its way back out into the blood. In obesity, fat builds up in the liver. The fat comes both straight from the diet and also from sugars that the liver turns into fat. As a result, the liver functions poorly.
Deane Morrison | EurekAlert!
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