Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Yale researchers identify molecule for detecting parasitic infection in humans

29.04.2005


Researchers at Yale, in collaboration with NIH researchers, have identified a specific protein molecule that is used by the immune system for detection of parasitic infections, leading the way for development of future vaccines to combat these infections.



Published in the April 28 issue of Science Express, the study provides insight into understanding how infectious parasites interface with the immune system--a problem of great scientific and clinical importance.

Most infections are caused by bacterial or viral microorganisms that produce molecules quite different from those produced by humans and other eukaryotic organisms. When microorganisms infect humans, the atypical molecules are usually detected immediately by human proteins called Toll-like receptors (TLR) that alert the human immune system to fight the infection.


But parasites, like humans, are eukaryotic in origin and how the body detects them has been a mystery.

The common parasite Toxoplasma gondii (T. gondii) causing toxoplasmosis, has a complicated life cycle in which it is transmitted from mice to cats and then to humans. Previous research had shown that T. gondii is recognized by a TLR and that the recognition of this parasite is crucial for an appropriate immune response. However, it was unclear which of the 13 different TLRs present in mammals was responsible and which molecule of T. gondii was being recognized by the TLRs.

"In this study we found that the recognition of T. gondii by the innate immune system is mediated by a new member of the TLR family, TLR 11, that we discovered last year," said Sankar Ghosh, professor of immunobiology at Yale School of Medicine. "We further found that the specific recognition molecule was Toxoplasma profilin. The innate immune system has the capacity to recognize these proteins and the profilins are the triggers."

Ghosh said that although parasitic infections are less prominent in the United States than bacterial and viral infections, the global impact of parasitic infections on health is tremendous. "Insight obtained from these studies should lead to development of novel strategies to combat these infections," he said. "In particular, an understanding of the parasite components that trigger a host immune response may facilitate the development of better vaccines."

Karen N. Peart | EurekAlert!
Further information:
http://www.yale.edu

More articles from Studies and Analyses:

nachricht Rutgers-led innovation could spur faster, cheaper, nano-based manufacturing
14.02.2018 | Rutgers University

nachricht New study from the University of Halle: How climate change alters plant growth
12.01.2018 | Martin-Luther-Universität Halle-Wittenberg

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Demonstration of a single molecule piezoelectric effect

Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale

Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...

Im Focus: Hybrid optics bring color imaging using ultrathin metalenses into focus

For photographers and scientists, lenses are lifesavers. They reflect and refract light, making possible the imaging systems that drive discovery through the microscope and preserve history through cameras.

But today's glass-based lenses are bulky and resist miniaturization. Next-generation technologies, such as ultrathin cameras or tiny microscopes, require...

Im Focus: Stem cell divisions in the adult brain seen for the first time

Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.

The generation of new nerve cells was once thought to taper off at the end of embryonic development. However, recent research has shown that the adult brain...

Im Focus: Interference as a new method for cooling quantum devices

Theoretical physicists propose to use negative interference to control heat flow in quantum devices. Study published in Physical Review Letters

Quantum computer parts are sensitive and need to be cooled to very low temperatures. Their tiny size makes them particularly susceptible to a temperature...

Im Focus: Autonomous 3D scanner supports individual manufacturing processes

Let’s say the armrest is broken in your vintage car. As things stand, you would need a lot of luck and persistence to find the right spare part. But in the world of Industrie 4.0 and production with batch sizes of one, you can simply scan the armrest and print it out. This is made possible by the first ever 3D scanner capable of working autonomously and in real time. The autonomous scanning system will be on display at the Hannover Messe Preview on February 6 and at the Hannover Messe proper from April 23 to 27, 2018 (Hall 6, Booth A30).

Part of the charm of vintage cars is that they stopped making them long ago, so it is special when you do see one out on the roads. If something breaks or...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

2nd International Conference on High Temperature Shape Memory Alloys (HTSMAs)

15.02.2018 | Event News

Aachen DC Grid Summit 2018

13.02.2018 | Event News

How Global Climate Policy Can Learn from the Energy Transition

12.02.2018 | Event News

 
Latest News

Fingerprints of quantum entanglement

16.02.2018 | Information Technology

'Living bandages': NUST MISIS scientists develop biocompatible anti-burn nanofibers

16.02.2018 | Health and Medicine

Hubble sees Neptune's mysterious shrinking storm

16.02.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>