Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

High risk of second cancers in survivors of childhood soft tissue sarcomas

25.04.2005


Children treated for soft tissue sarcomas have a significantly higher risk of developing subsequent cancers later in life, according to a new study. The study appears in the June 1, 2005 issue of CANCER (http://www.interscience.wiley.com/cancer-newsroom), a peer-reviewed journal of the American Cancer Society, and indicates children treated with combined chemotherapy and radiation therapy, in particular, had greater risks of developing a new malignancy.



With improvements in cancer treatments over the last two decades, children with soft tissue sarcomas are living longer. Several investigations have reported that these children have an increased risk of second cancer, but estimates of the risk have varied widely, ranging from three to thirteen times the risk among the general population. Moreover, due to the small size of many previous studies, few have evaluated risk by type of soft tissue sarcoma or have estimated risks for specific second cancers.

Randi J. Cohen, M.S. and a team of researchers from the National Cancer Institute (NCI) evaluated data from 1499 children included in one of the largest, most comprehensive cancer databases in the U.S., called the Surveillance, Epidemiology, and End Results (SEER) Program of the National Cancer Institute. Their goal was to quantify the risk of developing a second malignancy in soft tissue sarcoma patients by second cancer site, initial therapy, histologic type of the primary sarcoma, age at primary cancer diagnosis, and gender.


The investigators found that survivors of pediatric soft tissue sarcomas had a six-fold increased risk of developing a second cancer, as compared to the general population. However, the authors noted that while the relative risk appears high, the absolute risk is quite low. The NCI study found that approximately 3 percent of children with soft tissue sarcoma would be expected to develop a second malignancy by 20 years after their initial diagnosis. The relative risk was highest within the first five years of post-treatment follow-up. Females had slightly higher risks of second cancers than males; however, when gender-specific cancers of the breast and genital tract were excluded, the risks were identical.

Cohen et al. also found that second cancer risks were increased for all subtypes of childhood soft tissue sarcoma, with estimates ranging from 6-fold elevations in risk for fibromatous neoplasms to nearly 8-fold risks for rhabdomyosarcoma. Children initially treated with radiation or those with radiation combined with chemotherapy had substantially higher risks of second cancers than those treated with surgery alone.

Previous studies have reported increased risks of acute myelogenous leukemia following treatment of children with soft tissue sarcoma, particularly in those receiving chemotherapy for rhabdomyosarcoma. In addition, both clinical and registry-based surveys have reported that these children have an increased risk of second bone or soft tissue sarcoma, many of which were related to high dose radiation and chemotherapy or, in some cases, to genetic predisposition. In the current NCI study, the research team confirmed the excess of subsequent leukemia and sarcomas, but also found an increased risk of melanoma and cancers of the breast and oral cavity, although the results were based on small numbers. For several children the pattern of multiple cancers including soft tissue sarcomas was consistent with underlying genetic syndromes, particularly Li-Fraumeni syndrome and neurofibromatosis type 1.

The authors concluded, "both treatment effects and genetic factors contributed to the increased risk of second cancers in this series of children with soft tissue sarcomas."

David Greenberg | EurekAlert!
Further information:
http://www.wiley.com

More articles from Studies and Analyses:

nachricht Antarctic Ice Sheet mass loss has increased
14.06.2018 | Technische Universität Dresden

nachricht WAKE-UP provides new treatment option for stroke patients | International study led by UKE
17.05.2018 | Universitätsklinikum Hamburg-Eppendorf

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Overdosing on Calcium

Nano crystals impact stem cell fate during bone formation

Scientists from the University of Freiburg and the University of Basel identified a master regulator for bone regeneration. Prasad Shastri, Professor of...

Im Focus: AchemAsia 2019 will take place in Shanghai

Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.

Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...

Im Focus: First real-time test of Li-Fi utilization for the industrial Internet of Things

The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.

Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.

Im Focus: Sharp images with flexible fibers

An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.

Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...

Im Focus: Photoexcited graphene puzzle solved

A boost for graphene-based light detectors

Light detection and control lies at the heart of many modern device applications, such as smartphone cameras. Using graphene as a light-sensitive material for...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Munich conference on asteroid detection, tracking and defense

13.06.2018 | Event News

2nd International Baltic Earth Conference in Denmark: “The Baltic Sea region in Transition”

08.06.2018 | Event News

ISEKI_Food 2018: Conference with Holistic View of Food Production

05.06.2018 | Event News

 
Latest News

Carbon nanotube optics provide optical-based quantum cryptography and quantum computing

19.06.2018 | Physics and Astronomy

How to track and trace a protein: Nanosensors monitor intracellular deliveries

19.06.2018 | Life Sciences

New material for splitting water

19.06.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>