Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Study finds possible mechanism for link between sleep disturbances and metabolic syndrome

22.04.2005


A new mouse study suggests that a brain system that controls the sleep/wake cycle might also play a role in regulating appetite and metabolism. Mice with a mutation in a gene called "Clock," which helps drive circadian rhythm, ate significantly more and gained more weight. The finding could help explain why disrupted sleep patterns-particularly when combined with a high-fat diet--are associated with excessive weight gain and the onset of metabolic syndrome in some people, according to investigators supported by the National Institutes of Health (NIH).



The study, by Fred W. Turek, Ph.D., and Joseph Bass, M.D., Ph.D., of Northwestern University in Evanston, Ill., and others will be available at the Science Express website, http://www.sciencemag.org/sciencexpress/recent.shtml, on April 21, 2005.

The National Institute on Aging (NIA), the National Heart, Lung and Blood Institute (NHLBI), and the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) supported this work. The NIA, NHLBI and NIDDK are components of the NIH at the U.S. Department of Health and Human Services.


At least 40 million Americans have chronic sleep problems, and an additional 20 million experience occasional sleeping problems. As many as 47 million Americans have metabolic syndrome, a cluster of conditions shown to increase a person’s risk of heart disease and stroke. The National Cholesterol Education Program defines metabolic syndrome as having at least 3 of the following risk factors: high blood pressure, high glucose (sugar) levels which can indicate risk for diabetes, high triglyceride levels, low levels of good cholesterol, and a large waist.

Scientists have found that circadian rhythms (which control the sleep/wake cycle and other biological processes), hunger, and satiety are all regulated by centers within a brain structure called the hypothalamus. And previous studies in humans have suggested that disrupted sleep patterns may contribute to the development of obesity, diabetes, and metabolic syndrome.

In this latest work, Turek and his colleagues found that mutant mice were more active during times when rodents usually sleep. They also had less fluctuation in blood levels of leptin, a hormone that transmits a satiety signal to the brain. The researchers also found that Clock mutant mice had reduced levels of the hormone ghrelin within the hypothalamus, indicting that ghrelin may participate in the neuronal relay linking sleep, wakefulness, and appetite. Together, these alterations in neural and peripheral hormones suggest that a number of previously undetected brain circuits may exist that are common to sleep and eating.

The mice with a mutation in the Clock gene fed a regular diet gained about as much weight as normal mice that were fed a high-fat diet. The mice with a mutation in the Clock gene showed even greater weight gain and changes in metabolism when fed a high-fat diet. They developed a wide range of conditions associated with obesity, diabetes, and the metabolic syndrome, such as high levels of blood cholesterol, triglycerides, and glucose, and insulin resistance.

Andrew Monjan, Ph.D., of the NIA and Carl E. Hunt, M.D., director of the NIH National Center on Sleep Disorders Research, are available to discuss this study. To arrange an interview with Dr. Monjan, phone (301) 496-1752; for Dr. Hunt, phone (301) 496-4236.

NIA, NHLBI, and NIDDK are part of the National Institutes of Health (NIH), the Federal Government’s primary agency for biomedical and behavioral research. NIH is a component of the U.S. Department of Health and Human Services. NIA information on conditions and diseases associated with aging is available at www.nia.nih.gov. NHLBI press releases and fact sheets, including information on obesity and sleep disorders can be found online at www.nhlbi.nih.gov. NIDDK information on weight control and nutrition can be found online at www.niddk.nih.gov.

NHLBI Communications Office | EurekAlert!
Further information:
http://www.nhlbi.nih.gov
http://www.nia.nih.gov
http://www.niddk.nih.gov

More articles from Studies and Analyses:

nachricht New study: How does Europe become a leading player for software and IT services?
03.04.2017 | Fraunhofer-Institut für System- und Innovationsforschung (ISI)

nachricht Reusable carbon nanotubes could be the water filter of the future, says RIT study
30.03.2017 | Rochester Institute of Technology

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making lightweight construction suitable for series production

More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.

Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...

Im Focus: Wonder material? Novel nanotube structure strengthens thin films for flexible electronics

Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.

"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Fighting drug resistant tuberculosis – InfectoGnostics meets MYCO-NET² partners in Peru

28.04.2017 | Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

 
Latest News

Wireless power can drive tiny electronic devices in the GI tract

28.04.2017 | Medical Engineering

Ice cave in Transylvania yields window into region's past

28.04.2017 | Earth Sciences

Nose2Brain – Better Therapy for Multiple Sclerosis

28.04.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>