Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Study shows antibiotic treatment does not reduce risk of secondary cardiac events

21.04.2005


Taking antibiotics weekly for a year does not reduce the risk of a heart attack or other cardiac event for patients with stable coronary artery disease, according to a University of Washington study. The study was published in the April 22 edition of the New England Journal of Medicine.

Previous studies have found the bacteria Chlamydia pneumoniae in the arterial plaque of patients with coronary artery disease. Some doctors have reasoned that removal of C. pneumoniae from the system could reduce the risk of subsequent cardiac events. Prescription of antibiotics for this purpose had not been tested through a randomized clinical trial. The investigation of whether antibiotics could be used to treat the bacteria, and therefore reduce the risk of cardiac events, was conducted at 27 different sites in the United States.

All U.S. adults have been exposed to C. pneumoniae, which spreads through the air and causes pneumonia or mild repiratory disease, at some point in their lives.



This study, called the Azithromycin coronary events study, or ACES, found no benefit from treating the C. pneumoniae bacteria with an antibiotic in order to reduce the risk of heart attack or improve overall cardiac outcomes.

ACES researchers randomly assigned 4,012 men and women to receive either once-weekly doses of Azithromycin or a placebo for one year, starting in 1999. After an average follow-up of 3.9 years, there was no significant reduction of cardiac events, defined as death, heart attack, unstable angina, angioplasty or cardiac surgery, among participants receiving antibiotic compared to those given placebo. This lack of antibiotic effect was shown for all participants, regardless of age, gender, smoking status, or presence of C. pneumoniae antibody. The antibiotic treatment also had no effect on total mortality or on incidence of stroke.

Men and women were included in the study if they had stable coronary artery disease following a previous cardiac event such as a heart attack, angioplasty or cardiac bypass surgery. Azithromycin was selected because of its proven effectiveness against the C. pneumoniae bacteria and for its once-weekly dosing.

"This is conclusive evidence against using antibiotics to treat late stages of cardiovascular disease, but since the trial was not designed to study the role of C. pneumoniae in causing coronary heart disease, the ACES results do not tell us anything about a possible role of C. pneumoniae in the early development or acceleration of disease in the coronary arteries," said the study’s principal investigator, Dr. J. Thomas Grayston, professor of epidemiology in the University of Washington School of Public Health and Community Medicine. "More study is needed to determine the role of C. pneumoniae in heart disease."

Justin Reedy | EurekAlert!
Further information:
http://www.washington.edu

More articles from Studies and Analyses:

nachricht Amputees can learn to control a robotic arm with their minds
28.11.2017 | University of Chicago Medical Center

nachricht The importance of biodiversity in forests could increase due to climate change
17.11.2017 | Deutsches Zentrum für integrative Biodiversitätsforschung (iDiv) Halle-Jena-Leipzig

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Towards data storage at the single molecule level

The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.

Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...

Im Focus: Successful Mechanical Testing of Nanowires

With innovative experiments, researchers at the Helmholtz-Zentrums Geesthacht and the Technical University Hamburg unravel why tiny metallic structures are extremely strong

Light-weight and simultaneously strong – porous metallic nanomaterials promise interesting applications as, for instance, for future aeroplanes with enhanced...

Im Focus: Virtual Reality for Bacteria

An interdisciplinary group of researchers interfaced individual bacteria with a computer to build a hybrid bio-digital circuit - Study published in Nature Communications

Scientists at the Institute of Science and Technology Austria (IST Austria) have managed to control the behavior of individual bacteria by connecting them to a...

Im Focus: A space-time sensor for light-matter interactions

Physicists in the Laboratory for Attosecond Physics (run jointly by LMU Munich and the Max Planck Institute for Quantum Optics) have developed an attosecond electron microscope that allows them to visualize the dispersion of light in time and space, and observe the motions of electrons in atoms.

The most basic of all physical interactions in nature is that between light and matter. This interaction takes place in attosecond times (i.e. billionths of a...

Im Focus: A transistor of graphene nanoribbons

Transistors based on carbon nanostructures: what sounds like a futuristic dream could be reality in just a few years' time. An international research team working with Empa has now succeeded in producing nanotransistors from graphene ribbons that are only a few atoms wide, as reported in the current issue of the trade journal "Nature Communications."

Graphene ribbons that are only a few atoms wide, so-called graphene nanoribbons, have special electrical properties that make them promising candidates for the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

AKL’18: The opportunities and challenges of digitalization in the laser industry

07.12.2017 | Event News

Blockchain is becoming more important in the energy market

05.12.2017 | Event News

 
Latest News

Making fuel out of thick air

08.12.2017 | Life Sciences

Rules for superconductivity mirrored in 'excitonic insulator'

08.12.2017 | Information Technology

Smartphone case offers blood glucose monitoring on the go

08.12.2017 | Information Technology

VideoLinks
B2B-VideoLinks
More VideoLinks >>>