Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Newborn’s first week may be critical period for developing obesity in adulthood

19.04.2005


Babies who gain weight rapidly during their very first week of life may be more likely to be overweight as young adults, according to a new study. The research suggests that the first week may be a critical period for setting lifelong patterns of body weight.



Researchers from The Children’s Hospital of Philadelphia, the University of Pennsylvania and the University of Iowa studied 653 adults, ranging in age from 20 to 32. The subjects, all of whom were white, had been measured as newborns while participating in infant formula studies in Iowa. Those who had gained weight more rapidly during their first week were significantly more likely to be overweight decades later.

The research appears in the April 19 issue of Circulation, the journal of the American Heart Association. "Our main finding was that rapid weight gain during the first week of life in this population of healthy, European-American, formula-fed infants was associated with being overweight two to three decades later," said lead author Nicolas Stettler, M.D., M.S.C.E., a pediatric nutrition specialist at The Children’s Hospital of Philadelphia. "It suggests that there may be a critical period in that first week during which the body’s physiology may be programmed to develop chronic disease throughout life."


"Our findings also point toward new potential targets for preventing obesity," he added. "If these results are confirmed by other studies, they may lead to interventions in newborns to help prevent long-term development of obesity." Dr. Stettler explained, however, that such interventions have not yet been developed, and it is premature to make recommendations about specific targets for optimum weight gain.

"Normal weight gain is desirable for infants," he added. "Babies double their birth weight during the first four to six months. During the first week of life, however, a too-rapid gain in weight may increase the risk of future weight problems." After adjusting for other factors, Dr. Stettler’s team found that each additional 100 grams of weight gained during the first eight days increased a baby’s risk of becoming an overweight adult by about 10 percent.

The current research builds on several previous studies by Dr. Stettler and his collaborators focusing on rapid weight gain in infancy. They found that rapid weight gain during the first four months increased the risk of being overweight at age seven. They also found a higher rate of obesity at age 20 among African Americans who gained weight rapidly during the first four months.

The current study also revealed an association between rapid weight gain in the first four months (112 days) and being overweight in adulthood. However, the first week of life may be particularly sensitive. Why that first week of life plays such a critical role in affecting lifelong physiology remains an open question. "Animal studies have shown that overfeeding in the first few days of life lead to long-term obesity, possibly from programming in the developing brain or the endocrine system," said Dr. Stettler. "We don’t know how this effect may occur in humans. However, obesity is increasing in prevalence worldwide, and we hope our research may help contribute to ways to intervene in newborns to improve their lifelong health."

Given that participants in the current study all received infant formula, Dr. Stettler says, it may be relevant that exclusive breastfeeding during early infancy is known to be associated with a slower rate of weight gain, and possibly with a lower risk of overweight in childhood and adolescence. "For a variety of health reasons, the American Association of Pediatrics recommends exclusive breastfeeding during a baby’s first six months of life," says Dr. Stettler. "Although we cannot yet make specific recommendations about targets for newborn weight gain, we can certainly endorse breastfeeding."

Joey Marie McCool | EurekAlert!
Further information:
http://www.chop.edu

More articles from Studies and Analyses:

nachricht Multi-year study finds 'hotspots' of ammonia over world's major agricultural areas
17.03.2017 | University of Maryland

nachricht Diabetes Drug May Improve Bone Fat-induced Defects of Fracture Healing
17.03.2017 | Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

When Air is in Short Supply - Shedding light on plant stress reactions when oxygen runs short

23.03.2017 | Life Sciences

Researchers use light to remotely control curvature of plastics

23.03.2017 | Power and Electrical Engineering

Sea ice extent sinks to record lows at both poles

23.03.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>