Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Newborn’s first week may be critical period for developing obesity in adulthood

19.04.2005


Babies who gain weight rapidly during their very first week of life may be more likely to be overweight as young adults, according to a new study. The research suggests that the first week may be a critical period for setting lifelong patterns of body weight.



Researchers from The Children’s Hospital of Philadelphia, the University of Pennsylvania and the University of Iowa studied 653 adults, ranging in age from 20 to 32. The subjects, all of whom were white, had been measured as newborns while participating in infant formula studies in Iowa. Those who had gained weight more rapidly during their first week were significantly more likely to be overweight decades later.

The research appears in the April 19 issue of Circulation, the journal of the American Heart Association. "Our main finding was that rapid weight gain during the first week of life in this population of healthy, European-American, formula-fed infants was associated with being overweight two to three decades later," said lead author Nicolas Stettler, M.D., M.S.C.E., a pediatric nutrition specialist at The Children’s Hospital of Philadelphia. "It suggests that there may be a critical period in that first week during which the body’s physiology may be programmed to develop chronic disease throughout life."


"Our findings also point toward new potential targets for preventing obesity," he added. "If these results are confirmed by other studies, they may lead to interventions in newborns to help prevent long-term development of obesity." Dr. Stettler explained, however, that such interventions have not yet been developed, and it is premature to make recommendations about specific targets for optimum weight gain.

"Normal weight gain is desirable for infants," he added. "Babies double their birth weight during the first four to six months. During the first week of life, however, a too-rapid gain in weight may increase the risk of future weight problems." After adjusting for other factors, Dr. Stettler’s team found that each additional 100 grams of weight gained during the first eight days increased a baby’s risk of becoming an overweight adult by about 10 percent.

The current research builds on several previous studies by Dr. Stettler and his collaborators focusing on rapid weight gain in infancy. They found that rapid weight gain during the first four months increased the risk of being overweight at age seven. They also found a higher rate of obesity at age 20 among African Americans who gained weight rapidly during the first four months.

The current study also revealed an association between rapid weight gain in the first four months (112 days) and being overweight in adulthood. However, the first week of life may be particularly sensitive. Why that first week of life plays such a critical role in affecting lifelong physiology remains an open question. "Animal studies have shown that overfeeding in the first few days of life lead to long-term obesity, possibly from programming in the developing brain or the endocrine system," said Dr. Stettler. "We don’t know how this effect may occur in humans. However, obesity is increasing in prevalence worldwide, and we hope our research may help contribute to ways to intervene in newborns to improve their lifelong health."

Given that participants in the current study all received infant formula, Dr. Stettler says, it may be relevant that exclusive breastfeeding during early infancy is known to be associated with a slower rate of weight gain, and possibly with a lower risk of overweight in childhood and adolescence. "For a variety of health reasons, the American Association of Pediatrics recommends exclusive breastfeeding during a baby’s first six months of life," says Dr. Stettler. "Although we cannot yet make specific recommendations about targets for newborn weight gain, we can certainly endorse breastfeeding."

Joey Marie McCool | EurekAlert!
Further information:
http://www.chop.edu

More articles from Studies and Analyses:

nachricht New study: How does Europe become a leading player for software and IT services?
03.04.2017 | Fraunhofer-Institut für System- und Innovationsforschung (ISI)

nachricht Reusable carbon nanotubes could be the water filter of the future, says RIT study
30.03.2017 | Rochester Institute of Technology

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making lightweight construction suitable for series production

More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.

Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...

Im Focus: Wonder material? Novel nanotube structure strengthens thin films for flexible electronics

Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.

"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Fighting drug resistant tuberculosis – InfectoGnostics meets MYCO-NET² partners in Peru

28.04.2017 | Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

 
Latest News

Wireless power can drive tiny electronic devices in the GI tract

28.04.2017 | Medical Engineering

Ice cave in Transylvania yields window into region's past

28.04.2017 | Earth Sciences

Nose2Brain – Better Therapy for Multiple Sclerosis

28.04.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>