Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New treatment ’roadmap’ improves odds for unusual brain aneurysm

15.04.2005


A six-year study of a special type of brain aneurysm -- the thrombotic aneurysm -- has led to a treatment "roadmap" that should mean better outcomes for patients with this unusual medical problem.



UCSF Medical Center neurosurgeon Michael Lawton, MD, headed the clinical research team. The findings are reported in the March 2005 issue of Neurosurgery.

Approximately 5 percent of the U.S. population develops a brain aneurysm at some time, and an even smaller percentage -- about 0.5 percent -- is diagnosed with a thrombotic aneurysm. An aneurysm is an outpouching or bulge in an artery that usually forms at a branch point. The bulge represents a weakened spot in the arterial wall, and without treatment there is a risk of hemorrhage leading to brain damage or death. A thrombotic aneurysm is unusual because it contains a blood clot.


In surgical treatment for a brain aneurysm, tiny metal clips, something like tiny clothespins, are typically used to separate the aneurysm from the normal vessel. The clips keep blood from entering the aneurysm, and as a result future bleeding is prevented and nearby brain tissue is protected. A solid clot inside the aneurysm makes it difficult for the blades of the clip to squeeze the aneurysm and make the separation from the normal vessel.

In an attempt to develop better ways to treat patients with thrombotic aneurysms, the research team studied 68 patients with the disorder. The researchers developed a classification system of six different types of thrombotic aneurysms and the best way to treat each type.

At UCSF Medical Center, surgeons perform more than 400 brain aneurysm procedures a year, and while all are not thrombotic, when this type does arise it presents particular challenges to a neurosurgeon, according to Lawton.

"When confronted with a thrombotic aneurysm, the neurosurgeon’s instinct to clip collides with the solid mass of the aneurysm forcing him or her to trap the aneurysm between temporary clips...," the researchers write in the journal article. The next steps are to open the aneurysm wall, remove the blood clot from inside the aneurysm, and then reconstruct the neck of the aneurysm with clips. "This technique is stressful and the outcome unpredictable," they add, and can be associated with prolonged interruption of blood flow to the brain (known as ischemia), failed reconstructions, and poor results.

The study sought to address this with a classification system, giving the neurosurgeons more information on how to proceed with these challenging cases, Lawton said.

"There is little time to waste when a patient presents with an aneurysm," Lawton said. "The classification scheme may provide important preoperative guidance to neurosurgeons, increasing the chances of preserving the patient’s life and function."

Lawton likened the classification to a driver having a roadmap. "It puts the surgeon a couple of steps further ahead," he said.

All of the patients in the study had surgery performed by Lawton. There were 41 women and 27 men who ranged in age from 11 to 79 years old, with a mean age of 53. The aneurysm types were assigned by the other study investigators on the basis of preoperative radiographic studies independent of findings during surgery.

An important finding of the study was that, despite their solid mass, one-third of thrombotic aneurysms can be treated surgically with conventional clipping, the researchers noted.

In addition, the researchers discovered that patients with unclippable thrombotic aneurysms had more favorable results when treated with bypass and occlusion, rather than with thrombectomy (removal of the clot) and reconstruction of the parent arteries with clips. With aneurysm occlusion, the surgical team completely shuts down the affected artery, but in order to do that safely, blood flow is first rerouted around the aneurysm with a bypass. In a bypass procedure, a blood vessel is taken from another part of the body, usually the leg, and is grafted to a brain artery downstream from the aneurysm to maintain blood flow to that territory. This treatment therefore eliminates blood flow through an aneurysm while preserving flow to normal brain.

The journal report details, through description and illustration, the six classifications of thrombotic aneurysms. The aneurysms range from Type 1, which is the classic thrombotic aneurysm, to Type 6, in which the aneurysm was previously treated with implantation of coils. These tiny platinum coils are deployed into the aneurysm to block blood flow and prevent rupture.

Carol Hyman | EurekAlert!
Further information:
http://www.ucsf.edu

More articles from Studies and Analyses:

nachricht New study: How does Europe become a leading player for software and IT services?
03.04.2017 | Fraunhofer-Institut für System- und Innovationsforschung (ISI)

nachricht Reusable carbon nanotubes could be the water filter of the future, says RIT study
30.03.2017 | Rochester Institute of Technology

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can the immune system be boosted against Staphylococcus aureus by delivery of messenger RNA?

Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.

Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....

Im Focus: A quantum walk of photons

Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.

The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

 
Latest News

How herpesviruses win the footrace against the immune system

26.05.2017 | Life Sciences

Water forms 'spine of hydration' around DNA, group finds

26.05.2017 | Life Sciences

First Juno science results supported by University of Leicester's Jupiter 'forecast'

26.05.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>