Smad7 protein levels may predict therapy response
Levels of the Smad7 protein may predict therapeutic response in patients with prostate cancer according to research published today by investigators at the Uppsala Branch of the Ludwig Institute for Cancer Research (LICR).
"Although the 2-ME compound is in early clinical trials, no-one has fully understood the molecular mechanisms of how it causes the death of cancer cells, but not normal cells," says Dr. Maréne Landström, the senior author of the paper published in the prestigious Journal of Biological Chemistry. "We found that 2-ME works through a protein called Smad7, and that artificially lowering the amount of Smad7 in prostate cancer cells reduced 2-MEs ability to cause cell death. This finding suggests that the levels of Smad7, and other proteins in this molecular pathway, might predict the cell-killing ability of other cancer therapeutics and thus their effectiveness for treating individual patients."
Sarah L. White, Ph.D. | EurekAlert!
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