Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

SV40 not implicated in mesothelioma

07.04.2005


New highly sensitive approach shows no evidence of SV40 in tumors – SV40 unlikely to be factor in asbestos related cancers



SV40 does not have a role in the majority of malignant mesotheliomas -- a cancer associated with exposure to asbestos – according to a study in this month’s Cancer Research. The study, led by Mount Sinai School of Medicine researchers used a scrupulous protocol that eliminated contamination that has likely been the reason previous studies have implicated SV40 in this cancer.

"Ever since the connection between asbestos and mesothelioma was first identified there has been intense focus on finding a secondary cause that would explain why some individuals contract the disease while others who have equal exposure to asbestos do not," said James Manfredi, PhD, Associate Professor of Oncological Sciences at Mount Sinai School of Medicine.


The possibility that SV40 might be this secondary cause came to light when it was discovered that polio vaccines widely used in the 1960’s were contaminated with the virus. Recently, many studies have found low levels of SV40 in mesothelioma tumors.

Because SV40 must be present in every cell in order to block the functions of critical tumor suppressor proteins, Dr. Manfredi and colleagues argue that the low levels identified in tumors in earlier studies are insufficient to consider SV40 a cause of the cancers. Rather they explain that the SV40 found in these cells was likely the result of contamination.

"SV40 has been a widely used research model," explains Stuart Aaronson, MD, Professor and Chair of Oncological Sciences at Mount Sinai and co-author of the paper. "Since many DNA vectors used everyday in laboratories all over the world contain a portion of the SV40 genome it must be assumed that any sensitive test for SV40 might find this portion of the SV40 genome if rigorous methods aren’t used to exclude contamination."

In the current study, the researchers designed a scrupulous protocol with the specific intent of eliminating any possible contamination. They then used a highly sensitive assay, capable of detecting the virus even if it were only present in one out of 5,000 cells. None of the 69 tumors they tested contained detectable levels of SV40.

Mount Sinai Press Office | EurekAlert!
Further information:
http://www.mssm.edu

More articles from Studies and Analyses:

nachricht Antarctic Ice Sheet mass loss has increased
14.06.2018 | Technische Universität Dresden

nachricht WAKE-UP provides new treatment option for stroke patients | International study led by UKE
17.05.2018 | Universitätsklinikum Hamburg-Eppendorf

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: AchemAsia 2019 will take place in Shanghai

Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.

Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...

Im Focus: First real-time test of Li-Fi utilization for the industrial Internet of Things

The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.

Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.

Im Focus: Sharp images with flexible fibers

An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.

Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...

Im Focus: Photoexcited graphene puzzle solved

A boost for graphene-based light detectors

Light detection and control lies at the heart of many modern device applications, such as smartphone cameras. Using graphene as a light-sensitive material for...

Im Focus: Water is not the same as water

Water molecules exist in two different forms with almost identical physical properties. For the first time, researchers have succeeded in separating the two forms to show that they can exhibit different chemical reactivities. These results were reported by researchers from the University of Basel and their colleagues in Hamburg in the scientific journal Nature Communications.

From a chemical perspective, water is a molecule in which a single oxygen atom is linked to two hydrogen atoms. It is less well known that water exists in two...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Munich conference on asteroid detection, tracking and defense

13.06.2018 | Event News

2nd International Baltic Earth Conference in Denmark: “The Baltic Sea region in Transition”

08.06.2018 | Event News

ISEKI_Food 2018: Conference with Holistic View of Food Production

05.06.2018 | Event News

 
Latest News

A sprinkle of platinum nanoparticles onto graphene makes brain probes more sensitive

15.06.2018 | Materials Sciences

100 % Organic Farming in Bhutan – a Realistic Target?

15.06.2018 | Ecology, The Environment and Conservation

Perovskite-silicon solar cell research collaboration hits 25.2% efficiency

15.06.2018 | Power and Electrical Engineering

VideoLinks
Science & Research
Overview of more VideoLinks >>>