Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

SV40 not implicated in mesothelioma

07.04.2005


New highly sensitive approach shows no evidence of SV40 in tumors – SV40 unlikely to be factor in asbestos related cancers



SV40 does not have a role in the majority of malignant mesotheliomas -- a cancer associated with exposure to asbestos – according to a study in this month’s Cancer Research. The study, led by Mount Sinai School of Medicine researchers used a scrupulous protocol that eliminated contamination that has likely been the reason previous studies have implicated SV40 in this cancer.

"Ever since the connection between asbestos and mesothelioma was first identified there has been intense focus on finding a secondary cause that would explain why some individuals contract the disease while others who have equal exposure to asbestos do not," said James Manfredi, PhD, Associate Professor of Oncological Sciences at Mount Sinai School of Medicine.


The possibility that SV40 might be this secondary cause came to light when it was discovered that polio vaccines widely used in the 1960’s were contaminated with the virus. Recently, many studies have found low levels of SV40 in mesothelioma tumors.

Because SV40 must be present in every cell in order to block the functions of critical tumor suppressor proteins, Dr. Manfredi and colleagues argue that the low levels identified in tumors in earlier studies are insufficient to consider SV40 a cause of the cancers. Rather they explain that the SV40 found in these cells was likely the result of contamination.

"SV40 has been a widely used research model," explains Stuart Aaronson, MD, Professor and Chair of Oncological Sciences at Mount Sinai and co-author of the paper. "Since many DNA vectors used everyday in laboratories all over the world contain a portion of the SV40 genome it must be assumed that any sensitive test for SV40 might find this portion of the SV40 genome if rigorous methods aren’t used to exclude contamination."

In the current study, the researchers designed a scrupulous protocol with the specific intent of eliminating any possible contamination. They then used a highly sensitive assay, capable of detecting the virus even if it were only present in one out of 5,000 cells. None of the 69 tumors they tested contained detectable levels of SV40.

Mount Sinai Press Office | EurekAlert!
Further information:
http://www.mssm.edu

More articles from Studies and Analyses:

nachricht New study: How does Europe become a leading player for software and IT services?
03.04.2017 | Fraunhofer-Institut für System- und Innovationsforschung (ISI)

nachricht Reusable carbon nanotubes could be the water filter of the future, says RIT study
30.03.2017 | Rochester Institute of Technology

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

Im Focus: Using graphene to create quantum bits

In the race to produce a quantum computer, a number of projects are seeking a way to create quantum bits -- or qubits -- that are stable, meaning they are not much affected by changes in their environment. This normally needs highly nonlinear non-dissipative elements capable of functioning at very low temperatures.

In pursuit of this goal, researchers at EPFL's Laboratory of Photonics and Quantum Measurements LPQM (STI/SB), have investigated a nonlinear graphene-based...

Im Focus: Bacteria harness the lotus effect to protect themselves

Biofilms: Researchers find the causes of water-repelling properties

Dental plaque and the viscous brown slime in drainpipes are two familiar examples of bacterial biofilms. Removing such bacterial depositions from surfaces is...

Im Focus: Hydrogen Bonds Directly Detected for the First Time

For the first time, scientists have succeeded in studying the strength of hydrogen bonds in a single molecule using an atomic force microscope. Researchers from the University of Basel’s Swiss Nanoscience Institute network have reported the results in the journal Science Advances.

Hydrogen is the most common element in the universe and is an integral part of almost all organic compounds. Molecules and sections of macromolecules are...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

Innovation 4.0: Shaping a humane fourth industrial revolution

17.05.2017 | Event News

Media accreditation opens for historic year at European Health Forum Gastein

16.05.2017 | Event News

 
Latest News

New approach to revolutionize the production of molecular hydrogen

22.05.2017 | Materials Sciences

Scientists enlist engineered protein to battle the MERS virus

22.05.2017 | Life Sciences

Experts explain origins of topographic relief on Earth, Mars and Titan

22.05.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>