Bone SPECT is better than FDG PET for detecting breast cancer that has spread (metastasized) to a patient’s bones, according to researchers from Shizuoka Cancer Center Hospital in Japan.
FDG PET is an imaging technique based on the increased metabolism of glucose in tumor cells. SPECT is a type of nuclear medicine scan that detects special radioactive elements administered to the patient by the physician. According to the authors, due to these differences in method, bone SPECT images can reveal the location of bone metastases, whereas PET cannot. In addition, bone SPECT can detect where bone is being regenerated after destruction by tumor cells.
For the study, the researchers analyzed the findings in a total of 900 bones in 15 patients with breast cancer who underwent both SPECT and PET. They found that SPECT had a sensitivity of 85% and an accuracy of 96% for detecting bone metastases, whereas PET had a sensitivity of only 17% and an accuracy of 85%. They also found that PET was limited in its ability to reveal certain types of cancer lesions.
Jason Ocker | EurekAlert!
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