Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Infants needing a heart transplant can accept organs from different blood types

05.04.2005


New findings give infants a greater window of opportunity, better survival odds



A study showing that infants under one year of age can accept heart transplants from donors of different blood groups without the risk of organ rejection means a better chance of survival for infant patients and more efficient use of donor organs overall.
Results will be presented at the International Society for Heart and Lung Transplantation (ISHLT) Annual Meeting and Scientific Session in Philadelphia this week.

The study, published in Nature Medicine, shows that a heart from a donor with Type A blood can successfully be transplanted into an infant with Type O blood. Unlike older children and adults, babies do not yet have the antibodies that would normally reject antigens from a different blood type.



"The baby’s body educates itself to accept the organ and become tolerant of the blood type," says Lori West, MD, a pediatric cardiologist at the Hospital for Sick Children in Toronto and co-author of the study.

The body’s tolerance of a donor organ has always been one of the greatest challenges of transplant medicine. A cardinal rule is that a transplant from a mismatched donor results in the recipient rejecting the organ.

"The medical community has been trained that you just don’t cross that blood group barrier," says West. "For the first time, we have shown that the immune systems of human infants can tolerate intentional induction of B-cells to T-independent A and B antigens," says West. Other combinations have proved successful as well: "We have induced Type B to Type O, AB to O, A to B, etc., all with excellent results."

Many babies who undergo heart transplantation require a second donor heart at some point. The results of the study show that because the immune cells that would normally respond and attack the donor organ were eliminated with the first transplant, the patient can again receive a donor heart from that same blood type.

Known as the Toronto Protocol, the study originally involved fetal and infant mice and later, human babies, whose progress has been tracked for more than eight years. The Protocol has now been adopted at 15 medical centers around the world with similar successes at each of the centers.

"We found that the acceptance in mice and in humans occurs through the same processes," says West. "This means that what happens in mice tends to be successful in humans as well."

"This knowledge will save lives," says West. "More babies will survive congenital heart defects and go on to live fulfilling lives with a donor heart. We can use this knowledge to decrease the amount of time a patient must wait for a new heart – we’ll be able to use donor organs more efficiently and perform increasingly successful transplants."

Susan Speer | EurekAlert!
Further information:
http://www.ishlt.org/

More articles from Studies and Analyses:

nachricht The Great Unknown: Risk-Taking Behavior in Adolescents
19.01.2017 | Max-Planck-Institut für Bildungsforschung

nachricht A sudden drop in outdoor temperature increases the risk of respiratory infections
11.01.2017 | University of Gothenburg

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Helmholtz International Fellow Award for Sarah Amalia Teichmann

20.01.2017 | Awards Funding

An innovative high-performance material: biofibers made from green lacewing silk

20.01.2017 | Materials Sciences

Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery

20.01.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>