Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Infants needing a heart transplant can accept organs from different blood types

05.04.2005


New findings give infants a greater window of opportunity, better survival odds



A study showing that infants under one year of age can accept heart transplants from donors of different blood groups without the risk of organ rejection means a better chance of survival for infant patients and more efficient use of donor organs overall.
Results will be presented at the International Society for Heart and Lung Transplantation (ISHLT) Annual Meeting and Scientific Session in Philadelphia this week.

The study, published in Nature Medicine, shows that a heart from a donor with Type A blood can successfully be transplanted into an infant with Type O blood. Unlike older children and adults, babies do not yet have the antibodies that would normally reject antigens from a different blood type.



"The baby’s body educates itself to accept the organ and become tolerant of the blood type," says Lori West, MD, a pediatric cardiologist at the Hospital for Sick Children in Toronto and co-author of the study.

The body’s tolerance of a donor organ has always been one of the greatest challenges of transplant medicine. A cardinal rule is that a transplant from a mismatched donor results in the recipient rejecting the organ.

"The medical community has been trained that you just don’t cross that blood group barrier," says West. "For the first time, we have shown that the immune systems of human infants can tolerate intentional induction of B-cells to T-independent A and B antigens," says West. Other combinations have proved successful as well: "We have induced Type B to Type O, AB to O, A to B, etc., all with excellent results."

Many babies who undergo heart transplantation require a second donor heart at some point. The results of the study show that because the immune cells that would normally respond and attack the donor organ were eliminated with the first transplant, the patient can again receive a donor heart from that same blood type.

Known as the Toronto Protocol, the study originally involved fetal and infant mice and later, human babies, whose progress has been tracked for more than eight years. The Protocol has now been adopted at 15 medical centers around the world with similar successes at each of the centers.

"We found that the acceptance in mice and in humans occurs through the same processes," says West. "This means that what happens in mice tends to be successful in humans as well."

"This knowledge will save lives," says West. "More babies will survive congenital heart defects and go on to live fulfilling lives with a donor heart. We can use this knowledge to decrease the amount of time a patient must wait for a new heart – we’ll be able to use donor organs more efficiently and perform increasingly successful transplants."

Susan Speer | EurekAlert!
Further information:
http://www.ishlt.org/

More articles from Studies and Analyses:

nachricht Real-time feedback helps save energy and water
08.02.2017 | Otto-Friedrich-Universität Bamberg

nachricht The Great Unknown: Risk-Taking Behavior in Adolescents
19.01.2017 | Max-Planck-Institut für Bildungsforschung

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Stingless bees have their nests protected by soldiers

24.02.2017 | Life Sciences

New risk factors for anxiety disorders

24.02.2017 | Life Sciences

MWC 2017: 5G Capital Berlin

24.02.2017 | Trade Fair News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>