In the largest and most comprehensive prospective study of its kind, researchers at The University of Texas M. D. Anderson Cancer Center have concluded that the risk of ischemic heart disease and, ultimately, cardiac death following radiation treatment for breast cancer has steadily declined over the last quarter century, according to a new study published in the March 16 issue of the Journal of the National Cancer Institute.
This study offers scientific evidence to what was long thought to be true but never proven: that improvements in radiation techniques and delivery have greatly impacted radiation-associated cardiac mortality. "For a while now, physicians have been telling women that receiving radiation for breast cancer is so much safer today than it was before. People believed it, but there really was very little scientific evidence or studies examining the relationship between advancements in radiation therapy to ischemic heart disease," says Sharon Giordano, M.D., the studys lead author and an assistant professor in M. D. Andersons Department of Breast Medical Oncology. "Before now, there were no studies that looked at the effects of radiation to the heart over time. Most previous analyses had involved women who had been treated in the 1950s, 1960s and 1970s, decades not considered in the era of modern medicine. "Comparing women with breast cancer on the left side where the heart is located (therefore, more radiation is delivered to the heart) versus those with disease on the right side gave us a perfect study to examine radiation-induced toxicity to the heart and cardiac mortality," she continues.
Giordano and her colleagues used information from the National Cancer Institute SEER database (Surveillance, Epidemiology, and End Results), the authoritative source of information on cancer incidence and survival in the United States. The researchers analyzed SEER data from 1973 to 1989 on 27,283 women - 13,998 had left-sided breast cancer, 13,285 had right-sided breast cancer. Patients were stratified into three cohorts by date diagnosed - 1973 to 1979, 1980 to 1984 and 1985 to 1989. Mortality from ischemic heart disease, heart problems caused by narrowing of the arteries, was compared in the three cohorts.
Laura Sussman | EurekAlert!
Europe’s Demographic Future. Where the Regions Are Heading after a Decade of Crises
10.08.2017 | Berlin-Institut für Bevölkerung und Entwicklung
Scientists reveal source of human heartbeat in 3-D
07.08.2017 | University of Manchester
Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.
Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...
For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.
While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...
An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.
The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...
A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.
Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...
Researchers from the University of Miami (UM) Rosenstiel School of Marine and Atmospheric Science, the Italian Space Agency (ASI), and the Instituto Geofisico--Escuela Politecnica Nacional (IGEPN) of Ecuador, showed an increasing volcanic danger on Cotopaxi in Ecuador using a powerful technique known as Interferometric Synthetic Aperture Radar (InSAR).
The Andes region in which Cotopaxi volcano is located is known to contain some of the world's most serious volcanic hazard. A mid- to large-size eruption has...
16.08.2017 | Event News
04.08.2017 | Event News
26.07.2017 | Event News
16.08.2017 | Physics and Astronomy
16.08.2017 | Materials Sciences
16.08.2017 | Interdisciplinary Research