In the largest and most comprehensive prospective study of its kind, researchers at The University of Texas M. D. Anderson Cancer Center have concluded that the risk of ischemic heart disease and, ultimately, cardiac death following radiation treatment for breast cancer has steadily declined over the last quarter century, according to a new study published in the March 16 issue of the Journal of the National Cancer Institute.
This study offers scientific evidence to what was long thought to be true but never proven: that improvements in radiation techniques and delivery have greatly impacted radiation-associated cardiac mortality. "For a while now, physicians have been telling women that receiving radiation for breast cancer is so much safer today than it was before. People believed it, but there really was very little scientific evidence or studies examining the relationship between advancements in radiation therapy to ischemic heart disease," says Sharon Giordano, M.D., the studys lead author and an assistant professor in M. D. Andersons Department of Breast Medical Oncology. "Before now, there were no studies that looked at the effects of radiation to the heart over time. Most previous analyses had involved women who had been treated in the 1950s, 1960s and 1970s, decades not considered in the era of modern medicine. "Comparing women with breast cancer on the left side where the heart is located (therefore, more radiation is delivered to the heart) versus those with disease on the right side gave us a perfect study to examine radiation-induced toxicity to the heart and cardiac mortality," she continues.
Giordano and her colleagues used information from the National Cancer Institute SEER database (Surveillance, Epidemiology, and End Results), the authoritative source of information on cancer incidence and survival in the United States. The researchers analyzed SEER data from 1973 to 1989 on 27,283 women - 13,998 had left-sided breast cancer, 13,285 had right-sided breast cancer. Patients were stratified into three cohorts by date diagnosed - 1973 to 1979, 1980 to 1984 and 1985 to 1989. Mortality from ischemic heart disease, heart problems caused by narrowing of the arteries, was compared in the three cohorts.
Laura Sussman | EurekAlert!
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Pan-European study on “Smart Engineering”
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The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.
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Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
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Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
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In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
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