Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

HIV is not an independent risk factor for severe heart disease

09.03.2005


Infection with human immunodeficiency virus (HIV) is no longer an automatic death sentence, thanks to the use of highly active anti-retroviral therapy (HAART). However, several studies questions have suggested that HIV infection poses a serious threat to the heart -- specifically, that HIV positivity leads to an increased risk for the development of angiographically severe coronary artery disease (CAD). But Emory research presented by Amar D. Patel, MD, today at the American College of Cardiology (ACC) 54th Annual Scientific Sessions in Orlando today reaches a different conclusion.



Emory researchers studied all patients who underwent cardiac catheterization (due to acute coronary syndrome or an abnormal cardiac stress test) at Grady Memorial Hospital in Atlanta between January 2001 and December 2001. The patients were evaluated for HIV infection, common cardiac risk factors, HAART, and findings on coronary angiography. "We then used multivariate analyses to determine the relationship between HIV status and angiographically severe CAD in 525 patients," explains Emory Heart Center cardiologist and research team member Srikanth Sola, MD. "We found that 5 percent were HIV positive and 21 percent were admitted with a heart attack. But only 1.4 percent of the heart attack group was HIV positive."

Cardiac catheterization revealed that 213 patients (45%) had severe CAD stenosis and 14 patients of these patients were HIV positive. "At first, it appeared that HIV status was significantly associated with angiographically severe heart disease. However, after we adjusted for age, gender, hypertension, diabetes, high cholesterol levels and tobacco use, HIV status was no longer associated with severe CAD," says Dr. Sola. "In fact, there was no significant relationship between angiographically significant CAD and HAART, CD4 count, or HIV viral load."


The Emory researchers concluded that, although HIV infection is common in an urban population referred for cardiac catheterization, it was not a significant risk factor for severe CAD. "This suggests that factors other than HIV play a significant role in the development of severe CAD in patients who are HIV positive. Lifestyle and traditional cardiac risk factors (hypertension, hyperlipidemia, tobacco, etc.) appear to play a larger role than HIV in the development of CAD," Dr. Sola states.

He adds that the researchers were surprised by their findings. "We expected to see a strong relationship between HIV status and angiographically significant CAD," Dr. Sola says. "However, earlier studies were conducted in an era when effective therapy against HIV was not available. At that time, the severity of HIV infection may have been greater, leading to the association between HIV infection and CAD that was noted in these earlier studies."

In addition to Dr. Sola and Dr. Patel, the Emory research team included Tarek Helmy, MD (principal investigator); Divya Gupta, MD; Muhammad Mir, MD; Megan Price, MD; Patrick Caneer, MD; Faiz Cheema, MD; and Bobby Khan, MD.

Sherry Baker | EurekAlert!
Further information:
http://www.emory.edu

More articles from Studies and Analyses:

nachricht Smart Data Transformation – Surfing the Big Wave
02.12.2016 | Fraunhofer-Institut für Angewandte Informationstechnik FIT

nachricht Climate change could outpace EPA Lake Champlain protections
18.11.2016 | University of Vermont

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

Im Focus: Molecules change shape when wet

Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water

In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...

Im Focus: Fraunhofer ISE Develops Highly Compact, High Frequency DC/DC Converter for Aviation

The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.

Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

UTSA study describes new minimally invasive device to treat cancer and other illnesses

02.12.2016 | Medical Engineering

Plasma-zapping process could yield trans fat-free soybean oil product

02.12.2016 | Agricultural and Forestry Science

What do Netflix, Google and planetary systems have in common?

02.12.2016 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>