Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Asthma relapse in children common, possible risk factors identified

08.03.2005


One-third of children with asthma who go into remission by the age of 18 will relapse and redevelop asthma by the time they are 26, says a new study published in the March issue of CHEST, the peer-reviewed journal of the American College of Chest Physicians. The findings also suggest that children with certain common allergies, such as house dust mite sensitivity, and/or poor lung function are more likely to redevelop asthma following remission.



"While we cannot definitively explain why some individuals experience asthma relapse and others do not, we found that persistence of asthma and asthma relapse are significantly increased in children with house dust mite sensitivity," said study author, Malcolm R. Sears, MB, ChB, FRCPC, McMaster University, Hamilton, Ontario, Canada. "This is likely due to persistent inflammation and genetic factors."

In a longitudinal, population-based, cohort study of 1,037 children born in New Zealand between 1972 and 1973, researchers from Dunedin, New Zealand, and Hamilton, ON, Canada, looked at factors that influenced the reoccurrence of asthma by early adulthood. Study participants were given respiratory questionnaires and spirometry testing at ages 9, 11, 13, 15, 18, 21, and 26, as well as additional lung function and allergen skin-prick testing at select ages. Of 868 patients evaluated at age 18, 176 (20.3 percent) had physician-diagnosed asthma during childhood, and, of those, 68 (38.6 percent) no longer experienced any asthma symptoms (measured by self-reported wheezing). During an eight-year follow-up period, researchers found that 24 of the 68 study participants (35 percent) who had previously gone into remission, relapsed by age 26. Although not statistically significant, the patients who relapsed more often had allergies to house dust mites, grass, cats, dogs, and mold; poorer lung function (measured by FEV1/FVC ratios at age 18); and increased frequency of responsiveness to methacholine or bronchodilator at age 21.


"I think that if our patient database was larger or if the study period was longer, our findings that atopy and poor lung function predict the likelihood of relapse in the future would prove to be true at statistically significant levels," said Dr. Sears. "By not smoking and avoiding occupations that increase the likelihood of developing asthma, patients can help protect themselves from asthma relapse."

The study also found that children who were more sensitive to house dust mites and cat allergens and/or had poor lung function were significantly less likely to experience asthma remission by the time they were age 18. Of those in remission at age 18, the poorer their lung function, the more likely they were to relapse. For those who relapsed by age 21 or 26, their asthma was generally milder than patients who had persistent asthma throughout their childhood and into adulthood. Nine percent of those without prior asthma or wheezing by the age of 18 developed adult asthma by the time they were 26 years of age.

"This study demonstrates the role that specific risk factors have on asthma remission," said Paul A. Kvale, MD, FCCP, President of the American College of Chest Physicians. "As specialists who see these patients regularly, we must develop management programs to reduce the likelihood of relapse."

Arielle Green | EurekAlert!
Further information:
http://www.chestnet.org

More articles from Studies and Analyses:

nachricht WAKE-UP provides new treatment option for stroke patients | International study led by UKE
17.05.2018 | Universitätsklinikum Hamburg-Eppendorf

nachricht First form of therapy for childhood dementia CLN2 developed
25.04.2018 | Universitätsklinikum Hamburg-Eppendorf

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Powerful IT security for the car of the future – research alliance develops new approaches

The more electronics steer, accelerate and brake cars, the more important it is to protect them against cyber-attacks. That is why 15 partners from industry and academia will work together over the next three years on new approaches to IT security in self-driving cars. The joint project goes by the name Security For Connected, Autonomous Cars (SecForCARs) and has funding of €7.2 million from the German Federal Ministry of Education and Research. Infineon is leading the project.

Vehicles already offer diverse communication interfaces and more and more automated functions, such as distance and lane-keeping assist systems. At the same...

Im Focus: Molecular switch will facilitate the development of pioneering electro-optical devices

A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.

The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

In focus: Climate adapted plants

25.05.2018 | Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

 
Latest News

In focus: Climate adapted plants

25.05.2018 | Event News

Flow probes from the 3D printer

25.05.2018 | Machine Engineering

Less is more? Gene switch for healthy aging found

25.05.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>