Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Most older people with mild cognitive impairment have AD or cerebral vascular disease

08.03.2005


Mild cognitive impairment in older people is not a normal part of growing old but rather appears to be an indicator of Alzheimer’s disease or cerebral vascular disease, according to a study published in the March 8 issue of the journal, Neurology.



"The study shows that mild cognitive impairment is often the earliest clinical manifestation of one or both of two common age-related neurologic diseases," said Dr. David A. Bennett, director of the Rush Alzheimer’s Disease Center at Rush University Medical Center and the principal author of the paper. "From a clinical standpoint, even mild loss of cognitive function in older people should not be viewed as normal, but as an indication of a disease process," said Bennett.

This is the first study involving a large number of subjects who were followed until they developed mild cognitive impairment or dementia, and then died.. The study involved examining brain tissue from 180 people, including 37 with mild cognitive impairment, 60 without cognitive impairment, and the rest with dementia. All were Catholic nuns, priest or brothers who agreed to participate in the National Institute on Aging (NIA) funded Religious Orders Study. Since 1993 more than 1000 persons have agreed to annual clinical evaluations and to donate their brains to the Rush investigators at the time of death.


Study participants took tests of memory, language, attention and other cognitive abilities each year to document their clinical status. The diagnosis of mild cognitive impairment (MCI) was made when impaired performance on these tests was not severe enough to warrant a diagnosis of dementia. After death, the investigators measured the amount of Alzheimer’s disease pathology and cerebral infarcts (strokes) through brain autopsy. Of the 37 individuals with MCI, more than half (23) met pathologic criteria for Alzheimer’s disease, and nearly a third (12) had cerebral infarcts (this include five with both). Less than a quarter (9) did not have either pathology.

"Because most people with mild cognitive impairment progress to dementia, it has been difficult to obtain brain tissue from persons who die while they still have the condition," said Bennett. "We now know that both clinically and pathologically, mild cognitive impairment patients are in the middle in terms of the disease process for Alzheimer’s disease and cerebral vascular disease," said Bennett.

One positive finding from the study is that one-third (60) of the total study participants with an average age of 85 did not experience cognitive decline over several years of follow-up. Yet, about half of these persons had significant Alzheimer’s disease pathology and nearly a quarter had cerebral vascular disease. "It is likely that these individuals have some type of ’reserve’ capacity in their brains that allows them to escape the loss of memory despite the accumulation of pathology," said Bennett.

Bennett and his colleagues are involved in another NIA funded study at Rush, the Memory and Aging Project, trying to identify what keeps these individuals from becoming impaired. "Preventing the accumulation of disease pathology is a common approach to disease prevention," said Bennett. "Another way to prevent loss of cognition is to identify factors that protect us from becoming forgetful despite this pathology.

"From a public health perspective, the number of people with cognitive loss due to Alzheimer’s disease and cerebral vascular disease is probably much larger than current estimates," said Bennett. He hopes that these data provide additional impetus to research efforts to develop treatments and, ultimately, prevention for these common diseases of aging.

The study is funded by the National Institute on Aging.

John Pontarelli | EurekAlert!
Further information:
http://www.rush.edu

More articles from Studies and Analyses:

nachricht WAKE-UP provides new treatment option for stroke patients | International study led by UKE
17.05.2018 | Universitätsklinikum Hamburg-Eppendorf

nachricht First form of therapy for childhood dementia CLN2 developed
25.04.2018 | Universitätsklinikum Hamburg-Eppendorf

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

Im Focus: Entangled atoms shine in unison

A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.

The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

Designer cells: artificial enzyme can activate a gene switch

22.05.2018 | Life Sciences

PR of MCC: Carbon removal from atmosphere unavoidable for 1.5 degree target

22.05.2018 | Earth Sciences

Achema 2018: New camera system monitors distillation and helps save energy

22.05.2018 | Trade Fair News

VideoLinks
Science & Research
Overview of more VideoLinks >>>