A new study finds men treated with hormone therapy for prostate cancer may experience temporary cognitive changes that can affect verbal fluency, visual recognition and visual memory. The study, published in the April 1, 2005 issue of CANCER, a peer-reviewed journal of the American Cancer Society, finds the degree of cognitive dysfunction appeared to be related to a decline in serum estradiol brought on by hormonal treatment.
Androgen-deprivation therapy (AD) is an effective adjuvant therapy in the treatment of prostate cancer. It effectively reduces levels of testosterone, which acts as a tumor stimulant, and estradiol, a form of estrogen in men. Testosterone and estradiol are known to be important in neurological development and play a particularly important role in the cognitive areas of learning and memory. Previous studies in women have shown declining estradiol levels to effect cognition but until now little data existed in men.
Eeva Salminen, M.D. and colleagues at Turku University Hospital in Turku, Finland investigated the relationship between serum estradiol and cognitive functioning in men with prostate cancer treated with androgen-deprivation therapy.
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