Study in New England Journal of Medicine finds treatment significantly reduces bleeding in brain, decreases mortality by nearly 40% and reduces long-term disability for most deadly, least treatable form of stroke
A new multi-center, international study led by Columbia University Medical Center researchers at NewYork-Presbyterian Hospital/Columbia shows that recombinant activated factor VII (rFVIIa) has the potential to be a significant advance in treating bleeding stroke (acute intracerebral hemorrhage or ICH). Published in the New England Journal of Medicine (Feb. 24 issue), the study found a reduction in hematoma growth (bleeding in the brain), decreased mortality, and improvement in neurological and clinical outcomes in patients treated with rFVIIa compared to placebo.
ICH is the deadliest and most disabling type of stroke – more than one out of three ICH patients die within one month of onset and only 20% regain functional independence. Physicians have long been frustrated by a lack of effective therapies to improve survival outcomes or recovery – current options are only supportive. RFVIIa is currently entering phase III trials as an investigational treatment for ICH. If approved by the U.S. Food and Drug Administration, it will become only the second emergency treatment for stroke in more than three decades – the first was TPA, approved by the FDA in 1996.
Columbia University Medical Center’s Department of Neurology is one of the largest in the country, and is internationally recognized for pioneering research in the development of new treatment modalities and protocols for stroke. Columbia researchers recently won a highly competitive $12 million stroke center grant from the NIH. Columbia is the first site in the eastern United States to receive this Specialized Programs of Translational Research in Acute Stroke (SPOTRIAS) grant. Extending over five years, the funding will support three new research projects: one of the first clinical trials of statin medications as a potential stroke treatment; an imaging study of brain reorganization caused by stroke; and a novel stroke educational and behavior modification program.
Columbia University Medical Center provides international leadership in basic, pre-clinical and clinical research, medical education, and health care. The medical center trains future leaders in health care and includes the dedicated work of many physicians, scientists, nurses, dentists, and other health professionals at the College of Physicians & Surgeons, the School of Dental & Oral Surgery, the School of Nursing, the Mailman School of Public Health, the biomedical departments of the Graduate School of Arts and Sciences, and allied research centers and institutions. With a strong history of some of the most important advances and discoveries in health care, its researchers are leading the development of novel therapies and advances to address a wide range of health conditions.
Elizabeth Streich | EurekAlert!
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