Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Once-daily cystic fibrosis drug offers simpler home treatment and fewer side effects for children

11.02.2005


Nottingham researchers have found a way to treat children with cystic fibrosis (CF), which could reduce their side effects and see more young patients treated at home.



Experts at The University of Nottingham organised the largest successful clinical trial in the UK looking at cystic fibrosis in an attempt to discover whether a common antibiotic used to treat the condition could be administered just once a day instead of the usual three daily doses.

The recommendations from the study, which included CF patients from Nottingham City Hospital and will be published in The Lancet this week, could lead to simpler home treatment with less disruption to patients and their families.


The study was funded with £404,464 from the Cystic Fibrosis Trust, as part of their UK-wide work to improve clinical support for people with cystic fibrosis and help find a cure for this disease.

One of the patients who took part in the study was 17-year-old Kayleigh Boden. Kayleigh, an A-level student from Welton near Lincoln, found that her side effects reduced and she liked being able to administer her drugs just once a day at 4pm rather than the usual three times a day, including a midnight shift.

“The drugs usually lead to tinnitus and headaches and my eyes are affected, but I definitely suffered fewer side effects during the trial,” she added.

Kayleigh hopes that administering her drugs just once a day will help her to effectively manage her condition while allowing her to lead an active life that will include sitting her exams in the summer and, hopefully, achieving her ambition of going to university to train as a quantity surveyor.

Cystic fibrosis is the UK’s most common life-threatening inherited disease. Sufferers have difficulty in digesting food and are vulnerable to chronic chest infections. Every week five babies are born with CF and three people die from the condition — 90 per cent from the lung damage, which often results from chronic chest infections.

Patients are frequently given prolonged courses of intravenous antibiotics to treat chronic chest infections, often for two weeks or more. This treatment may be needed every few months and can interfere with children’s schooling or adults studying or getting work. Sometimes intravenous treatment is given at home rather than in hospital to make this easier. However, administering this treatment puts an extra strain on parents, partners or the patient themselves.

In an effort to make home treatment easier, the team in the University’s Division of Respiratory Medicine, led by Professor Alan Knox and Dr Alan Smyth, organised the TOPIC (Tobramycin Once-daily Prescribing In Cystic fibrosis) national trial.

The researchers are based at the study’s co-ordinating centre, Nottingham City Hospital, where they care for 80 children with CF and travel out to see another 80 children at five other hospitals. The hospital also has a busy adult clinic treating more than 100 patients.

The study looked at tobramycin, a commonly-used antibiotic, to see if it would be effective when given once a day rather than the usual three times daily treatment. The drug can potentially lead to reduced kidney function and hearing loss. However, the TOPIC team found that once daily treatment worked just as well and seemed to have fewer side effects in children.

Rosie Barnes, Chief Executive of the Cystic Fibrosis Trust, said: “This is a very encouraging and exciting piece of research not least because of the immediate impact on patients. It will help relieve what is very time-consuming care and reduce the amount of time spent taking the required dose of antibiotics.”

The team is now looking at new ways to help people with CF. Current projects are looking at the role of garlic capsules against chest infection and whether home treatment can be simplified further by giving a second antibiotic as a 24-hour infusion through a small pump device.

Dr Alan Smyth | alfa
Further information:
http://www.nottingham.ac.uk

More articles from Studies and Analyses:

nachricht New study: How does Europe become a leading player for software and IT services?
03.04.2017 | Fraunhofer-Institut für System- und Innovationsforschung (ISI)

nachricht Reusable carbon nanotubes could be the water filter of the future, says RIT study
30.03.2017 | Rochester Institute of Technology

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

Im Focus: Using graphene to create quantum bits

In the race to produce a quantum computer, a number of projects are seeking a way to create quantum bits -- or qubits -- that are stable, meaning they are not much affected by changes in their environment. This normally needs highly nonlinear non-dissipative elements capable of functioning at very low temperatures.

In pursuit of this goal, researchers at EPFL's Laboratory of Photonics and Quantum Measurements LPQM (STI/SB), have investigated a nonlinear graphene-based...

Im Focus: Bacteria harness the lotus effect to protect themselves

Biofilms: Researchers find the causes of water-repelling properties

Dental plaque and the viscous brown slime in drainpipes are two familiar examples of bacterial biofilms. Removing such bacterial depositions from surfaces is...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

Innovation 4.0: Shaping a humane fourth industrial revolution

17.05.2017 | Event News

 
Latest News

Scientists propose synestia, a new type of planetary object

23.05.2017 | Physics and Astronomy

Zap! Graphene is bad news for bacteria

23.05.2017 | Life Sciences

Medical gamma-ray camera is now palm-sized

23.05.2017 | Medical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>