Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Columbia study suggests brushing your teeth may reduce risk of stroke and heart attack

08.02.2005


Columbia University Medical Center research illustrates connection between periodontal disease and atherosclerosis



A new study by researchers at Columbia University Medical Center provides the most direct evidence to date that preventing gum disease could significantly improve your chances of avoiding vascular problems.

The study, which appears in the February 8 edition of the American Heart Association’s publication Circulation, shows that people with gum disease are more likely to suffer from atherosclerosis – a narrowing of blood vessels that can lead to stroke or heart attack.


Previous studies have suggested a relationship between periodontal disease and vascular disease, but they have relied on surrogate markers for periodontal disease, such as tooth loss or pocket depth. This is the first study to examine the microbiology of periodontal infection and positively connect it to atherosclerosis.

"This is the most direct evidence yet that gum disease may lead to stroke or cardiovascular disease," said Moïse Desvarieux, M.D., Ph.D., assistant professor of Epidemiology at Columbia University Medical Center’s Mailman School of Public Health and lead author of the paper. "And because gum infections are preventable and treatable, taking care of your oral health could very well have a significant impact on your cardiovascular health."

Columbia researchers measured the bacteria levels in the mouths of 657 people who had no history of stroke or myocardial infarction. They also measured the thickness of the subjects’ carotid arteries – the artery that are measured to identify atherosclerosis. The researchers found that people with a higher level of the specific bacteria that causes periodontal disease also had an increased carotid artery thickness, even after taking other cardiovascular risk factors into account.

Desvarieux and his colleagues showed that in these people, atherosclerosis is associated specifically with the type of bacteria that causes periodontal disease, and not with other oral bacteria. They confirmed this by assessing the levels of three different groups of microbes – those that are known to cause periodontal disease, those that are thought to possibly cause periodontal disease, and those that are not connected to the disease. The relationship between atherosclerosis and oral bacteria only existed for bacteria causally related to periodontitis. The research is part of the NIH- funded INVEST (Oral INfections and Vascular Disease Epidemiology STudy) at Columbia University Medical Center and the University of Minnesota and the NINDS-funded Northern Manhattan Study.

According to Dr. Desvarieux, one possible explanation for the link is that the bacteria that cause the gum disease may migrate throughout the body via the bloodstream and stimulate the immune system, causing inflammation that results in the clogging of arteries.

"It is important that we have shown an association between specific periodontal pathogens and carotid artery thickness that is unique and unrelated to other oral bacteria", said Panos N. Papapanou, D.D.S., Ph.D., professor and chair of the Section of Oral and Diagnostic Sciences and director of the Division of Periodontics, Columbia University School of Dental & Oral Surgery, and a co-author on the study whose laboratory performed the periodontal microbiological analysis.

"The measurement of carotid arteries thickness, which has been shown to be a strong predictor of stroke and heart attacks, was performed in our ultrasound lab without knowledge of the subjects’ periodontal status to ensure an unbiased evaluation of cardiovascular health," said Ralph L. Sacco, M.D., M.S, associate chair of Neurology, professor of Neurology and Epidemiology, and director of the Stroke and Critical Care Division of the Columbia University College of Physicians and Surgeons and a co-author of the study.

"This study is an example of the multidisciplinary alliance of strong epidemiologic design and methods, microbiology and imaging," said Dr. Desvarieux, who is principal investigator of the study. "We will continue to study these patients to determine if atherosclerosis continues over time and is definitively associated with periodontal disease."

Also participating in the study were David Jacobs, Ph.D. professor of Epidemiology at the University of Minnesota, Tatjana Rundek, MD, and Bernadette Boden-Albala, assistant professors of neurology at Columbia and Ryan Demmer, a doctoral student at the University Of Minnesota who works with Dr. Desvarieux.

Craig LeMoult | EurekAlert!
Further information:
http://www.columbia.edu

More articles from Studies and Analyses:

nachricht The personality factor: How to foster the sharing of research data
06.09.2017 | ZBW – Leibniz-Informationszentrum Wirtschaft

nachricht Europe’s Demographic Future. Where the Regions Are Heading after a Decade of Crises
10.08.2017 | Berlin-Institut für Bevölkerung und Entwicklung

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: The pyrenoid is a carbon-fixing liquid droplet

Plants and algae use the enzyme Rubisco to fix carbon dioxide, removing it from the atmosphere and converting it into biomass. Algae have figured out a way to increase the efficiency of carbon fixation. They gather most of their Rubisco into a ball-shaped microcompartment called the pyrenoid, which they flood with a high local concentration of carbon dioxide. A team of scientists at Princeton University, the Carnegie Institution for Science, Stanford University and the Max Plank Institute of Biochemistry have unravelled the mysteries of how the pyrenoid is assembled. These insights can help to engineer crops that remove more carbon dioxide from the atmosphere while producing more food.

A warming planet

Im Focus: Highly precise wiring in the Cerebral Cortex

Our brains house extremely complex neuronal circuits, whose detailed structures are still largely unknown. This is especially true for the so-called cerebral cortex of mammals, where among other things vision, thoughts or spatial orientation are being computed. Here the rules by which nerve cells are connected to each other are only partly understood. A team of scientists around Moritz Helmstaedter at the Frankfiurt Max Planck Institute for Brain Research and Helene Schmidt (Humboldt University in Berlin) have now discovered a surprisingly precise nerve cell connectivity pattern in the part of the cerebral cortex that is responsible for orienting the individual animal or human in space.

The researchers report online in Nature (Schmidt et al., 2017. Axonal synapse sorting in medial entorhinal cortex, DOI: 10.1038/nature24005) that synapses in...

Im Focus: Tiny lasers from a gallery of whispers

New technique promises tunable laser devices

Whispering gallery mode (WGM) resonators are used to make tiny micro-lasers, sensors, switches, routers and other devices. These tiny structures rely on a...

Im Focus: Ultrafast snapshots of relaxing electrons in solids

Using ultrafast flashes of laser and x-ray radiation, scientists at the Max Planck Institute of Quantum Optics (Garching, Germany) took snapshots of the briefest electron motion inside a solid material to date. The electron motion lasted only 750 billionths of the billionth of a second before it fainted, setting a new record of human capability to capture ultrafast processes inside solids!

When x-rays shine onto solid materials or large molecules, an electron is pushed away from its original place near the nucleus of the atom, leaving a hole...

Im Focus: Quantum Sensors Decipher Magnetic Ordering in a New Semiconducting Material

For the first time, physicists have successfully imaged spiral magnetic ordering in a multiferroic material. These materials are considered highly promising candidates for future data storage media. The researchers were able to prove their findings using unique quantum sensors that were developed at Basel University and that can analyze electromagnetic fields on the nanometer scale. The results – obtained by scientists from the University of Basel’s Department of Physics, the Swiss Nanoscience Institute, the University of Montpellier and several laboratories from University Paris-Saclay – were recently published in the journal Nature.

Multiferroics are materials that simultaneously react to electric and magnetic fields. These two properties are rarely found together, and their combined...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

“Lasers in Composites Symposium” in Aachen – from Science to Application

19.09.2017 | Event News

I-ESA 2018 – Call for Papers

12.09.2017 | Event News

EMBO at Basel Life, a new conference on current and emerging life science research

06.09.2017 | Event News

 
Latest News

Rainbow colors reveal cell history: Uncovering β-cell heterogeneity

22.09.2017 | Life Sciences

Penn first in world to treat patient with new radiation technology

22.09.2017 | Medical Engineering

Calculating quietness

22.09.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>