Understanding molecular double action of tzds to reduce side effects
In an attempt to find a new generation of diabetic drugs that will minimize side effects, researchers at the University of Pennsylvania School of Medicine report a new understanding of how thiazolidinediones (TZDs), widely used diabetic medications, work in fat cells. With yearly sales exceeding billions of dollars, TZDs – such as rosiglitazone maleate (Avandia) and pioglitazone hydrochloride (Actos) – help to maintain diabetics blood-sugar levels.
In fat cells, TZDs turn on a small set of genes, which arent normally turned on, by targeting the receptor PPARã. To tease out how the medications work specifically, the investigators set out to determine the difference between the genes that are ordinarily turned on in fat cells and the genes that are turned on only when diabetics are given the TZDs.
Karen Kreeger | EurekAlert!
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