Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Animal study shows link between nicotine and atrial flutter

27.01.2005


In a recent animal study, researchers from the Division of Cardiology at Cedars-Sinai Medical Center, in collaboration with the University of California, Los Angeles, have found that over time, the absorption of nicotine after myocardial infarction (MI) significantly increases the incidence of cardiac fibrosis in canine hearts. This reaction promotes a kind of rapid heart rhythm that has many similarities to typical human atrial flutter, a potentially life-threatening condition that affects approximately a quarter million Americans each year.



In an article published online in the January issue of the American Journal of Physiology: Heart and Circulatory Physiology, researchers report a study that tested the effects of nicotine on hearts with healed myocardial infarction. Numerous studies have shown that smoking promotes coronary heart disease and myocardial infarction and is a major cause of chronic obstructive pulmonary disease, an independent predictor of atrial flutter. These findings have raised the possibility that a causal link might exist between nicotine and atrial flutter in patients with myocardial infarction.

Atrial flutter is a type of rapid heart rate caused by the upper chambers of the heart (the right and left atria). The resulting rhythm is so rapid (about 400 beats/min) that the atria are not able to fully empty their contents into the ventricles, and the "left behind" blood stagnates, increasing the risk of thromboembolism and stroke. Fibrosis is an abnormal condition in which fibrous connective tissue spreads over or replaces smooth muscle; it is most common in the heart, lung, peritoneum and kidney.


"Although there were anecdotal reports, this hypothesis had not been previously tested systematically as to the reaction between nicotine and disease in promoting cardiac arrhythmias," said Hrayr Karagueuzian, Ph.D., senior research scientist in the Division of Cardiology at Cedars-Sinai and senior author on the study. "We knew a significant portion of patients with heart disease had an increased incidence of atrial flutter, but there weren’t any explanations as to the mechanistic basis or the need for concomitant disease."

Myocardial infarction, or heart attack, occurs when the supply of blood to the heart is suddenly and severely reduced or cut off, causing the muscle to die from lack of oxygen. In the study, the condition was created surgically in anesthetized lab animal hearts by permanent occlusion of the left anterior descending coronary artery. Nicotine was administered for one month using osmotic mini-pumps with a dose similar to that absorbed by heavy smokers. An osmotic pump is a tiny implantable device that functions somewhat like an intravenous tube, delivering agents (in this case, nicotine) through a semi-permeable membrane.

The study included four groups. Those with only an MI and surgery experienced no flutter. Similarly, those that underwent surgery and received nicotine, but had no MI, also did not experience any flutter; nor did those that did not have surgery or nicotine. The final group, however, which had an MI, along with surgery and nicotine, did experience atrial flutter.

"Nicotine caused a significant increase in atrial interstitial fibrosis (a two-fold increase in the left atrium and a 10-fold increase in the right atrium) in the myocardial infarction group but only a two-fold increase in the right atrium in the non-MI group," according to Karagueuzian. Furthermore, "chronic nicotine caused a kind of atrial electrical remodeling (change) that encourages the maintenance of a single stable wavefront allowing the atrial flutter to be sustained unperturbed" added Karagueuzian. The scientists were able to replicate the findings in computer simulations.

According to the American Heart Association, people who smoke a pack of cigarettes a day have more than twice the risk of heart attack than people who’ve never smoked; and smokers who have a heart attack have less chance of surviving than nonsmokers. The Centers for Disease Control and Prevention reports that cigarette smoking results in a two-to-three fold risk of dying from coronary heart disease. From 1995 to 1999, an average of 442,398 Americans died each year of smoking-related illnesses; 33.5 percent of these deaths were cardiovascular-related.

"We were surprised to find that nicotine induced a considerable increase in atrial interstitial fibrosis in the dogs with myocardial infarction but only a mild increase in the dogs with no MI," Karagueuzian said. "These differential effects on atrial fibrosis occurred despite the fact that nicotine blood levels were similar in both groups and within the range seen in smokers."

According to Karagueuzian, "To the extent that this animal model may be representative of human atrial flutter, our findings may be valuable in determining the pathogenesis of human typical atrial flutter and eventually helping to identify a therapeutic target for preventing fibrosis and atrial flutter."

More immediately, Karagueuzian hopes the study will give smokers a better understanding of the mechanisms of nicotine-induced heart disease and that they will take a second look at reducing their habit or stopping it entirely and permanently.

Sandra Van | EurekAlert!
Further information:
http://www.cedars-sinai.edu

More articles from Studies and Analyses:

nachricht A sudden drop in outdoor temperature increases the risk of respiratory infections
11.01.2017 | University of Gothenburg

nachricht Urbanization to convert 300,000 km2 of prime croplands
27.12.2016 | Mercator Research Institute on Global Commons and Climate Change (MCC) gGmbH

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

Im Focus: How to inflate a hardened concrete shell with a weight of 80 t

At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).

Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

Nothing will happen without batteries making it happen!

05.01.2017 | Event News

 
Latest News

A big nano boost for solar cells

18.01.2017 | Power and Electrical Engineering

Glass's off-kilter harmonies

18.01.2017 | Materials Sciences

Toward a 'smart' patch that automatically delivers insulin when needed

18.01.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>