Researchers led by a Brigham and Womens Hospital/Harvard Medical School team found that wheezing -- a key physiological component of asthma -- requires the interaction of genes in several locations. The work, involving multiple independent verification, demonstrates the complexity of the genetic predisposition to asthma.
The study, "Interacting genetic loci cause airway hyperresponsiveness," appears online in Physiological Genomics, published by the American Physiological Society. "We know that there are both genetic and environmental factors that cause people to develop asthma," Dr. Kate G. Ackerman, the lead researcher, stated. "We have now shown that the genetic inheritance of wheezing, one component of asthma, is extremely complex in our model. This suggests that the discovery of these genes in the human population will be difficult and will require a multi-locus approach."
After the study on the airway hyperresponsiveness (AHR) trait, Dr. David R. Beier, the laboratory leader, said: "In the specific case of asthma, hopefully these results will direct human studies to look for genetic influences in a combinatorial fashion." Using an elaborate mouse model, the researchers found that the wheezing trait unambiguously required the interaction of loci on different chromosomes, yet analysis of the individual chromosomes showed no significant association with wheezing. (A locus is a site on a chromosome where the gene for a particular trait is located.)
Mayer Resnick | EurekAlert!
Do microplastics harbour additional risks by colonization with harmful bacteria?
05.04.2018 | Leibniz-Institut für Ostseeforschung Warnemünde
Rutgers-led innovation could spur faster, cheaper, nano-based manufacturing
14.02.2018 | Rutgers University
University of Connecticut researchers have created a biodegradable composite made of silk fibers that can be used to repair broken load-bearing bones without the complications sometimes presented by other materials.
Repairing major load-bearing bones such as those in the leg can be a long and uncomfortable process.
Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.
Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...
Novel highly efficient and brilliant gamma-ray source: Based on model calculations, physicists of the Max PIanck Institute for Nuclear Physics in Heidelberg propose a novel method for an efficient high-brilliance gamma-ray source. A giant collimated gamma-ray pulse is generated from the interaction of a dense ultra-relativistic electron beam with a thin solid conductor. Energetic gamma-rays are copiously produced as the electron beam splits into filaments while propagating across the conductor. The resulting gamma-ray energy and flux enable novel experiments in nuclear and fundamental physics.
The typical wavelength of light interacting with an object of the microcosm scales with the size of this object. For atoms, this ranges from visible light to...
Stable joint cartilage can be produced from adult stem cells originating from bone marrow. This is made possible by inducing specific molecular processes occurring during embryonic cartilage formation, as researchers from the University and University Hospital of Basel report in the scientific journal PNAS.
Certain mesenchymal stem/stromal cells from the bone marrow of adults are considered extremely promising for skeletal tissue regeneration. These adult stem...
In the fight against cancer, scientists are developing new drugs to hit tumor cells at so far unused weak points. Such a “sore spot” is the protein complex...
13.04.2018 | Event News
12.04.2018 | Event News
09.04.2018 | Event News
20.04.2018 | Physics and Astronomy
20.04.2018 | Interdisciplinary Research
20.04.2018 | Physics and Astronomy