In the first study of its kind, researchers say half of patients undergoing stem cell transplantation exhibit signs of delirium, but the warning signs are subtler and can be easily missed by clinicians. The study, which appears in the February 15, 2005 issue of CANCER, a peer-reviewed journal of the American Cancer Society, says the level of distress, fatigue, and pain are associated with the severity of delirium.
Delirium is a temporary, acute change in a patients level of consciousness and cognition or perception that is caused by a medical condition. Classically, clinicians identify delirium by the presence of hallucinations, delusions, agitation, and disorientation. However, delirium appears to present itself in two prognostic categories: transient with less clinical significance and prolonged with greater clinical significance. Delirium is associated with a higher risk of falls, wound infections, and aspiration pneumonia. In cancer patients, delirium is further associated with increased risk of death during hospitalization and within five years of follow-up. While treatable with medications and appropriate care, delirium is underdiagnosed and undertreated, which can result in poor outcomes, patient and caregiver distress, and over-utilization of healthcare resources.
In order to improve clinical recognition of delirium in patients undergoing hematopoietic stem cell treatment (HSCT), Jesse R. Fann, M.D., M.P.H. of the University of Washingtons Department of Psychiatry and Behavioral Sciences and Fred Hutchinson Cancer Research Centers Division of Clinical Research and his colleagues followed 90 patients from before transplant to 30 days post-transplant and described the symptoms and time course as well as risk factors associated with delirium.
David Greenberg | EurekAlert!
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Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.
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Let’s say the armrest is broken in your vintage car. As things stand, you would need a lot of luck and persistence to find the right spare part. But in the world of Industrie 4.0 and production with batch sizes of one, you can simply scan the armrest and print it out. This is made possible by the first ever 3D scanner capable of working autonomously and in real time. The autonomous scanning system will be on display at the Hannover Messe Preview on February 6 and at the Hannover Messe proper from April 23 to 27, 2018 (Hall 6, Booth A30).
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