Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Unique presentation of delirium after stem cell transplantation

10.01.2005


In the first study of its kind, researchers say half of patients undergoing stem cell transplantation exhibit signs of delirium, but the warning signs are subtler and can be easily missed by clinicians. The study, which appears in the February 15, 2005 issue of CANCER, a peer-reviewed journal of the American Cancer Society, says the level of distress, fatigue, and pain are associated with the severity of delirium.



Delirium is a temporary, acute change in a patient’s level of consciousness and cognition or perception that is caused by a medical condition. Classically, clinicians identify delirium by the presence of hallucinations, delusions, agitation, and disorientation. However, delirium appears to present itself in two prognostic categories: transient with less clinical significance and prolonged with greater clinical significance. Delirium is associated with a higher risk of falls, wound infections, and aspiration pneumonia. In cancer patients, delirium is further associated with increased risk of death during hospitalization and within five years of follow-up. While treatable with medications and appropriate care, delirium is underdiagnosed and undertreated, which can result in poor outcomes, patient and caregiver distress, and over-utilization of healthcare resources.

In order to improve clinical recognition of delirium in patients undergoing hematopoietic stem cell treatment (HSCT), Jesse R. Fann, M.D., M.P.H. of the University of Washington’s Department of Psychiatry and Behavioral Sciences and Fred Hutchinson Cancer Research Center’s Division of Clinical Research and his colleagues followed 90 patients from before transplant to 30 days post-transplant and described the symptoms and time course as well as risk factors associated with delirium.


The authors found 50 percent of patients had delirium episodes, which could be categorized into three distinct clusters of symptoms: 1) psychotic and behavioral problems, 2) cognitive impairment, and 3) disturbance of mood and consciousness. Early symptoms began about four days prior to the start of the episode and lasted an average of 10 days, peaking at the end of the second week after transplantation. These symptoms included hypoactive behavior, sleep-wake cycle disturbance, and cognitive impairment. Simultaneous complaints of emotional distress, fatigue, and pain were strongly associated with delirium occurrence.

This study demonstrates that clinicians cannot rely on classic presentations such as hallucinations and agitation to recognize delirium in this patient population. Instead, the authors conclude, "more subtle symptoms of hypoactive psychomotor behavior, altered sleep-wake cycle, and impaired attention and working memory should be early indicators for increased monitoring and identification of possible causes of delirium."

David Greenberg | EurekAlert!
Further information:
http://www.wiley.com

More articles from Studies and Analyses:

nachricht New study: How does Europe become a leading player for software and IT services?
03.04.2017 | Fraunhofer-Institut für System- und Innovationsforschung (ISI)

nachricht Reusable carbon nanotubes could be the water filter of the future, says RIT study
30.03.2017 | Rochester Institute of Technology

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making lightweight construction suitable for series production

More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.

Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...

Im Focus: Wonder material? Novel nanotube structure strengthens thin films for flexible electronics

Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.

"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

7th International Conference on Crystalline Silicon Photovoltaics in Freiburg on April 3-5, 2017

03.04.2017 | Event News

 
Latest News

Scientist invents way to trigger artificial photosynthesis to clean air

26.04.2017 | Materials Sciences

Ammonium nitrogen input increases the synthesis of anticarcinogenic compounds in broccoli

26.04.2017 | Agricultural and Forestry Science

SwRI-led team discovers lull in Mars' giant impact history

26.04.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>