Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Timing is everything for optimum combined cancer therapy

21.12.2004


Agents designed to attack blood vessels that feed a growing tumor are effective against tumor growth in laboratory experiments. However, results of early clinical trials with these inhibitors have not yet exhibited the same success observed in animal models. Now, a new study published in the December issue of Cancer Cell demonstrates that a unique time period exists during which combined radiation and antiangiogenic therapy can exert a remarkable synergistic effect that significantly slows tumor growth.



Recent clinical studies have suggested that antiangiogenic therapy is most effective when delivered in combination with radiation or chemotherapy. However, evidence supporting combined therapies has been inconsistent. Dr. Rakesh K. Jain from the Steele Laboratory for Tumor Biology at Massachusetts General Hospital and Harvard Medical School led a study to investigate whether the timing of combined therapy impacts treatment effectiveness.

Mice implanted with gliomas were treated with radiation, with the antiangiogenic agent DC101, or with combinations of the two. DC101 blocks the action of VEGF, a protein that stimulates blood vessel formation and is found at very high levels in gliomas. Blood vessels in gliomas and many other tumors are abnormal and do not deliver oxygen to tumor cells as efficiently as normal blood vessels do in normal tissues. This is clinically significant because lack of oxygen, or hypoxia, can make a tumor resistant to radiation therapy.


The researchers found that antiangiogenic therapy passively pruned some of the immature blood vessels of tumors and actively recruited pericytes, cells that support a blood vessel, to temporarily stabilize the tumor vasculature. During this period of vascular normalization, tumor hypoxia was substantially decreased and the effect of radiation treatment was enhanced. These results demonstrate that antiangiogenic therapy not only reduces the density of blood vessels in a tumor but, for a short time, makes the existing tumor vasculature more like that of normal tissues, thereby facilitating oxygen delivery to the tumor and enhancing the effects of radiation treatment.

"The time course of this vascular normalization should be taken into account when radiation and antiangiogenic therapy are combined," suggests Dr. Jain. He further speculates that, "If the time course of vascular changes induced by VEGF blockade is taken into account, one might achieve a survival advantage greater than the five months seen in the recent landmark clinical trial of combination therapy."

Heidi Hardman | EurekAlert!
Further information:
http://www.cell.com

More articles from Studies and Analyses:

nachricht Drone vs. truck deliveries: Which create less carbon pollution?
31.05.2017 | University of Washington

nachricht New study: How does Europe become a leading player for software and IT services?
03.04.2017 | Fraunhofer-Institut für System- und Innovationsforschung (ISI)

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can we see monkeys from space? Emerging technologies to map biodiversity

An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.

Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

Im Focus: Scientists develop molecular thermometer for contactless measurement using infrared light

Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine

Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

Quantum thermometer or optical refrigerator?

23.06.2017 | Physics and Astronomy

A 100-year-old physics problem has been solved at EPFL

23.06.2017 | Physics and Astronomy

Equipping form with function

23.06.2017 | Information Technology

VideoLinks
B2B-VideoLinks
More VideoLinks >>>