Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Yo-yo diet redistributes toxins in body tissue; Olestra+caloric cut boosts toxic excretion

20.12.2004


Perhaps Ukrainian Viktor Yushchenko should try olestra to get rid of dioxin. It’s worked before. A new study shows how diet affects chlorinated hydrocarbons trapped in body fat and how olestra raises their excretion rate up to 30-fold.



Perhaps Ukrainian opposition leader Viktor Yushchenko should try an "Olestra diet" to rid his body of dioxin. It wouldn’t be the first time that the "fake fat" product was used as an emergency agent to flush out dioxin, one of a group of chlorinated hydrocarbons that are toxic, lipophilic (attracted to fat) – and persistent in the environment and animal tissues. About five years ago, two Austrian women suffering from dioxin poisoning were given olestra snacks, which resulted in removal of dioxin at 10 times the normal rate, according to some reports.

In an as-yet-unpublished study, researchers at the University of Cincinnati School of Medicine, along with Trevor Redgrave at the University of Western Australia, treated a patient with PCB toxicity over a two-year period with olestra in the form of fat-free Pringles. The patient’s chloracne disappeared and the PCB level in fat tissue dropped dramatically.


The same University of Cincinnati School of Medicine team is reporting new research that sheds light into how diet affects retention and re-distribution through the weight gain-loss-regain cycle of chlorinated hydrocarbons, which include DDT, PCBs and dioxins. They also looked at the effects of the additive olestra, which is made by Procter & Gamble, on this redistribution and perhaps more importantly, on excretion of toxins from the body.

Indeed, "combined dietary olestra and caloric restriction caused a 30-fold increase in the rate of excretion" of a test toxin, while the toxin’s distribution "into the brain resulting from the restricted diet was reduced by 50% by dietary olestra," the study found.

The study, "Effects of yo-yo diet, caloric restriction, and olestra on tissue distribution of hexachlorobenzene," was conducted by Ronald J. Jandacek, Nicole Anderson, Min Liu, Shuqin Zheng, Qing Yang and Patrick Tso of the Department of Pathology and Laboratory Medicine, University of Cincinnati School of Medicine, Cincinnati, Ohio. The research appears in the online edition of the American Journal of Physiology-Gastrointestinal and Liver Physiology, published by the American Physiological Society.

They’re everywhere, and with long half-lives

Toxic lipophilic substances like PCBs and dioxins are so widespread globally, and are known to ascend the food chain, that virtually "all people tested have measurable levels of some of these compounds," the Jandacek et al. report notes. Because the compounds and many of their metabolites are lipophilic (attracted to fat) they are stored in adipose (fat) tissue where they remain stable, usually without adverse affect in moderate amounts for their long half-lives.

Jandacek and his colleagues designed a multi-branch, multi-endpoint study that showed with weight loss (with and without olestra) toxins redistribute around the body, but with differing affinity to various organs.

Method and results: brain, adipose and liver tissue differences

The Cincinnati researchers used 14C-hexachlorobenzene (14C-HCB), a radioactively-marked toxin that is only partly metabolized by mice, to measure how its distribution changed in various organs during the weight gain-loss yo-yo process.

They found that continued "weight loss resulted in a three-fold increase of 14C amount and concentration in the brain. After weight regain, 14C in the brain decreased but then increased again after a second weight loss." In adipose tissue, weight loss resulted in an increase in the concentration of 14C without changing the total amount in the fat tissue. "Weight loss and regain resulted in an increase of 14C in the liver that reflected an increase of fat in the liver," Jandacek et al. reported.

At this point, the regimen of weight gain and loss was repeated in mice gavaged (direct-fed to the stomach) with 14C-HCB, with one group receiving the "non-absorbable fat, olestra" in their diet. The results were striking: "Combined dietary olestra and caloric restriction caused a 30-fold increase in the rate of excretion of 14C, relative to an ad lib diet or a reduced caloric (diet) alone. The distribution of 14C into the brain resulting from the restricted diet was reduced by 50% by dietary olestra," Jandacek et al. reported.

Next steps

The results of the current study have indicated several avenues to pursue, among them being:

  • Plasma HCB increased with prolonged caloric restriction, indicating the need for future studies into the possible role of carriers of HCB.
  • HCB was cleared more rapidly from chylomicrons than triacylglycerol, "suggesting an affinity of organochlorines for the fatty acids generated during fat metabolism."
  • "How plasma carriers facilitate HCB entry into the brain is an interesting question with potential physiological implications."
  • Jandacek’s laboratory is currently studying the relationship of fasting and refeeding to liver lipid deposition.
  • The exact role of olestra and its mechanism of action in the excretion process.
  • Whether and how different organochlorine compounds (PCBs, dioxins, etc.) undergo redistribution in yo-yo diet situations.
  • Testing a lipase inhibitor such as orlistat (Xenical, Roche) "will also result in partial blockage of the enterohepatic circulation of lipophiles by providing an undigested intestinal triacylglycerol phase that will solubilize these compounds."

Source and funding

The study, "Effects of yo-yo diet, caloric restriction, and Olestra on tissue distribution of hexachlorobenzene," by Jandacek et al. appears online in the American Journal of Physiology-Gastrointestinal and Liver Physiology, published by the American Physiological Society.

Mayer Resnick | EurekAlert!
Further information:
http://www.the-aps.org

More articles from Studies and Analyses:

nachricht Real-time feedback helps save energy and water
08.02.2017 | Otto-Friedrich-Universität Bamberg

nachricht The Great Unknown: Risk-Taking Behavior in Adolescents
19.01.2017 | Max-Planck-Institut für Bildungsforschung

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Biocompatible 3-D tracking system has potential to improve robot-assisted surgery

17.02.2017 | Medical Engineering

Real-time MRI analysis powered by supercomputers

17.02.2017 | Medical Engineering

Antibiotic effective against drug-resistant bacteria in pediatric skin infections

17.02.2017 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>