Wiping out a protein in skin cancer cells could significantly stall melanoma tumor development and increase the sensitivity of the cancer cells to chemotherapy, a Penn State College of Medicine study suggests.
The protein, Akt3, appears to be responsible for promoting tumor cell survival and development in 43 percent to 60 percent of non-inherited melanomas. "Our study showed that lowering Akt3 activity can reduce the tumor-creating potential of melanoma cells by making the cancer cells more likely to respond to signals that tell them to die," said Gavin P. Robertson, Ph.D., assistant professor of pharmacology, pathology and dermatology, Penn State College of Medicine. "Because most chemotherapeutic drugs work by inducing apoptosis, or programmed cell death, we predict that inhibiting Akt3 activity could lower the threshold doses of drugs or radiation required for effective chemo- or radiotherapy and provide a mechanism to directly target the melanoma cells."
The study, published recently in the journal Cancer Research, used melanoma cell lines together with tumors taken directly from melanoma patients to show that as melanoma cells become more aggressive and metastatic, the amount of active Akt3 protein in the cells increases.
Valerie Gliem | EurekAlert!
New study from the University of Halle: How climate change alters plant growth
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Physicists have developed a technique based on optical microscopy that can be used to create images of atoms on the nanoscale. In particular, the new method allows the imaging of quantum dots in a semiconductor chip. Together with colleagues from the University of Bochum, scientists from the University of Basel’s Department of Physics and the Swiss Nanoscience Institute reported the findings in the journal Nature Photonics.
Microscopes allow us to see structures that are otherwise invisible to the human eye. However, conventional optical microscopes cannot be used to image...
On the way to an intelligent laboratory, physicists from Innsbruck and Vienna present an artificial agent that autonomously designs quantum experiments. In initial experiments, the system has independently (re)discovered experimental techniques that are nowadays standard in modern quantum optical laboratories. This shows how machines could play a more creative role in research in the future.
We carry smartphones in our pockets, the streets are dotted with semi-autonomous cars, but in the research laboratory experiments are still being designed by...
What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...
For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.
Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...
At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.
No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...
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