For the first time scientists have demonstrated a model that may explain how alcohol stimulates tumor growth. Their study, published in the January 15, 2005 issue of CANCER,says alcohol fuels the production of a growth factor that stimulates blood vessel development in tumors, and that chronic ethanol increased tumor size and levels of the angiogenic factor and levels of the angiogenic factor and vascular endothelial growth factor (VEGF) in an experimental model.
For almost a hundred years mounting epidemiological evidence has linked alcohol use to an increased risk of cancers of the stomach, esophagus, liver, breast, and colon. Researchers have never developed an adequate model to explain how ethanol or a metabolite of ethanol may cause cancer. Hypotheses abound, and include such diverse theories as acetaldehyde carcinogenicity, dietary imbalances, and impaired nutrient metabolism and detoxification due to alcohol consumption, activation of precancerous enzymes, and suppression of the immune system.
Recent data in a cellular model has demonstrated that ethanol increases cellular production of VEGF, an important signaling protein in blood vessel growth, particularly in tumors. Jian-Wei Gu. M.D. from the University of Mississippi Medical Center and colleagues further investigated the possible mechanism between ethanol-induced blood vessel growth and VEGF using a chick embryo model. The investigators exposed chick embryos inoculated with fibrosarcoma cells to saline or physiologically relevant levels of ethanol for nine days.
The Great Unknown: Risk-Taking Behavior in Adolescents
19.01.2017 | Max-Planck-Institut für Bildungsforschung
A sudden drop in outdoor temperature increases the risk of respiratory infections
11.01.2017 | University of Gothenburg
An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...
Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...
Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.
While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...
Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales
Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...
Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.
As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...
19.01.2017 | Event News
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09.01.2017 | Event News
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20.01.2017 | Materials Sciences
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