Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New study links lead exposure with increased risk of cataract

13.12.2004


Results from a new study show that lifetime lead exposure may increase the risk of developing cataracts. Researchers found that men with high levels of lead in the tibia, the larger of the two leg bones below the knee, had a 2.5-fold increased risk for cataract, the leading cause of blindness and visual impairment.



"These results suggest that reducing exposure of the public to lead and lead compounds could lead to a significant decrease in the overall incidence of cataract," said Kenneth Olden, Ph.D., director of the National Institute of Environmental Health Sciences.

The National Institute of Environmental Health Sciences, one of the National Institutes of Health, provided support to researchers at the Harvard School of Public Health and Brigham and Women’s Hospital for the nine-year study, which is also focusing on lead’s contribution to hypertension and impairment of kidney and cognitive function. The findings on risk of cataract are published in the December 8th issue of the Journal of the American Medical Association. Lead is found in lead-based paint, contaminated soil, household dust, drinking water, lead crystal, and lead-glazed pottery. Following exposure to lead, the compound circulates in the bloodstream and eventually concentrates in the bone.


The Harvard researchers tested whether bone lead levels measured in both the tibia and patella, also known as the kneecap, were associated with cataract in an ongoing study of men taken from the Boston area. "Given the strong association between tibia lead and cataract in men, we estimate that lead exposure plays a significant role in approximately 42 percent of all cataracts in this population," said Debra Schaumberg, Sc.D., assistant professor of medicine and ophthalmology at Harvard Medical School and lead author of the study. "While lead in both the tibia and patella was associated with an increased risk of cataract, tibia lead was the best predictor of cataract in the study sample."

According to Schaumberg, cataracts develop as a result of cumulative injury to the crystalline lens of the eye. "Lead can enter the lens, resulting in gradual injury to certain proteins present in the epithelial cells, and this eventually results in a cataract," she said.

The Harvard researchers are among the first to use bone lead in studying the effect of lifetime lead exposure on disease risk. "The best biological marker for estimating a person’s cumulative exposure to lead is provided by skeletal lead," said Dr. Howard Hu, professor of occupational and environmental medicine at the Harvard School of Public Health and co-author of the study. "Since blood lead levels reflect only recent exposures, they are not likely to predict the development of age-related diseases such as cataract, which take many years to develop."

Cataracts, a clouding of the lens resulting in a partial loss of vision, are very common in older people. By age 80, more than half of all Americans either have a cataract or have had cataract surgery. Other risk factors for cataract include diabetes, smoking, long-term alcohol consumption, and prolonged exposure to ultraviolet sunlight.

The prevention of age-related cataract remains an important public health goal," said Schaumberg. "In addition to the obvious problems of reduced vision, the visual disability associated with cataracts can have a significant impact on the risk of falls, fractures, quality of life, and possibly even mortality."

John Peterson | EurekAlert!
Further information:
http://www.niehs.nih.gov

More articles from Studies and Analyses:

nachricht Real-time feedback helps save energy and water
08.02.2017 | Otto-Friedrich-Universität Bamberg

nachricht The Great Unknown: Risk-Taking Behavior in Adolescents
19.01.2017 | Max-Planck-Institut für Bildungsforschung

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Stingless bees have their nests protected by soldiers

24.02.2017 | Life Sciences

New risk factors for anxiety disorders

24.02.2017 | Life Sciences

MWC 2017: 5G Capital Berlin

24.02.2017 | Trade Fair News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>