Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Stressed mice quicker to get skin cancer

09.12.2004


Does stress speed up the onset of skin cancer? The answer, in mice anyway, appears to be "yes." Scientists at the Johns Hopkins Kimmel Cancer Center say that chronic stress may speed up the process in those at high-risk for the disease. Their new study, published in the December issue of the Journal of the American Academy of Dermatology, shows that mice exposed to stressful conditions and cancer-causing UV light develop skin cancers in less than half the time it took for non-stressed mice to grow tumors.



The Hopkins investigators say that if what they are seeing in mice has relevance in man, stress-reducing programs like yoga and meditation may help those at high risk for skin cancer stay healthy longer. "There’s a lot of evidence pointing to the negative effects of chronic stress, which dampens our immune system and impacts various aspects of our health," says Francisco Tausk, M.D., associate professor of dermatology at Johns Hopkins and director of the study. "But, to help create solid treatment strategies, we need a better understanding of the mechanisms of how stressors affect skin cancer development."

Tausk exposed 40 mice to the scent of fox urine - the mouse equivalent of big-time stress - and large amounts of UV light. The first skin tumor in one of the mice appeared after eight weeks of testing. Mice exposed only to UV light began developing tumors 13 weeks later. By 21 weeks of testing, 14 of the 40 stressed mice had at least one tumor, and two non-stressed mice had tumors. Most tumors were squamous cell skin cancers, also known as non-melanoma cancers, but which have the potential to spread to other parts of the body.


Chronic stress is known to suppress the activity of immune system cells that recognize foreign invading cells and target them for destruction. Acute stress, which is episodic and time-limited, such as parachuting or riding a roller coaster, may have the opposite effect of chronic stress. "Acute stress actually can rev up the immune system," Tausk says.

Tausk and his team will conduct more studies to find the cancer pathways influenced by chronic stress. "Stress reduction programs usually are a good option for many people, but we think they may be more important for individuals at high-risk for skin cancer," he says. Fair-skinned people exposed to large amounts of UV light and patients previously diagnosed with squamous cell skin cancer, genetic diseases or organ transplants that predispose them to the disease are considered high-risk. The investigators urge people concerned about their risk for skin cancer to speak with their health-care provider before starting any stress-reduction or exercise program.

This research was funded by the Johns Hopkins Center for Complementary and Alternative Medicine.

Participants in this research are Jason L. Parker, Sabra L. Klein, Warwick L. Morison, and Xaobu Ye from the Johns Hopkins; Martha McClintock from the University of Chicago; Claudio J. Conti from the M.D. Anderson Cancer Center; and Carlos Nousari from the University of Miami.

Vanessa Wasta | EurekAlert!
Further information:
http://www.hopkinskimmelcancercenter.org
http://www.hopkinsdermatology.org
http://www.jhmi.edu

More articles from Studies and Analyses:

nachricht The importance of biodiversity in forests could increase due to climate change
17.11.2017 | Deutsches Zentrum für integrative Biodiversitätsforschung (iDiv) Halle-Jena-Leipzig

nachricht Win-win strategies for climate and food security
02.10.2017 | International Institute for Applied Systems Analysis (IIASA)

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A “cosmic snake” reveals the structure of remote galaxies

The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.

Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...

Im Focus: Visual intelligence is not the same as IQ

Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.

That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...

Im Focus: Novel Nano-CT device creates high-resolution 3D-X-rays of tiny velvet worm legs

Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.

During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....

Im Focus: Researchers Develop Data Bus for Quantum Computer

The quantum world is fragile; error correction codes are needed to protect the information stored in a quantum object from the deteriorating effects of noise. Quantum physicists in Innsbruck have developed a protocol to pass quantum information between differently encoded building blocks of a future quantum computer, such as processors and memories. Scientists may use this protocol in the future to build a data bus for quantum computers. The researchers have published their work in the journal Nature Communications.

Future quantum computers will be able to solve problems where conventional computers fail today. We are still far away from any large-scale implementation,...

Im Focus: Wrinkles give heat a jolt in pillared graphene

Rice University researchers test 3-D carbon nanostructures' thermal transport abilities

Pillared graphene would transfer heat better if the theoretical material had a few asymmetric junctions that caused wrinkles, according to Rice University...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Ecology Across Borders: International conference brings together 1,500 ecologists

15.11.2017 | Event News

Road into laboratory: Users discuss biaxial fatigue-testing for car and truck wheel

15.11.2017 | Event News

#Berlin5GWeek: The right network for Industry 4.0

30.10.2017 | Event News

 
Latest News

NASA detects solar flare pulses at Sun and Earth

17.11.2017 | Physics and Astronomy

NIST scientists discover how to switch liver cancer cell growth from 2-D to 3-D structures

17.11.2017 | Health and Medicine

The importance of biodiversity in forests could increase due to climate change

17.11.2017 | Studies and Analyses

VideoLinks
B2B-VideoLinks
More VideoLinks >>>