Trial results presented at the Annual American Society of Hematology Conference
University of Minnesota researchers will present the promising results from adult umbilical cord blood studies for patients with cancers of the blood and bone marrow. These studies’ findings provide solutions to the problems outlined in recently published studies in the New England Journal of Medicine (NEJM). "The results of our studies are a triumph in a treatment that has been largely viewed as only possible in children and adolescents," said John Wagner, M.D., professor of pediatrics and scientific director of clinical research, Blood and Marrow Transplantation Program and Stem Cell Institute.
A major limitation of adult cord blood transplantation highlighted in the NEJM articles is the high likelihood of patients dying early after transplant. This likelihood is due to: poor recovery of the patient’s blood cell counts as a result of the relatively low number of cells in cord blood compared to bone marrow, or toxicity from the high doses of chemotherapy and radiation used in conventional transplant regimens.
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