An antimicrobial agent found in many shampoos and hand lotions and widely used in industrial settings inhibits the development of particular neuron structures that are essential for transmitting signals between cells, according to a University of Pittsburgh study presented today at Cell Biology 2004, the 44th annual meeting of the American Society for Cell Biology. The meeting is being held Dec. 4 – 8 at the Washington Convention Center.
Prolonged exposure to low levels of methylisothiazolinone (MIT) restricted growth of axons and dendrites of immature rat nerve cells in culture, apparently by disengaging the machinery of a key enzyme that is activated in response to cell-to-cell contact, and may have potentially damaging consequences to a developing nervous system, the researchers report. "While more research is needed to determine what effect MIT would have in rodent models, both at the cellular level and to a developing nervous system, our results thus far suggest there is potential that everyday exposure to the chemical could also be harmful to humans. I would be particularly concerned about occupational exposure in pregnant women and the possibility of risk to the fetus," said senior author Elias Aizenman, Ph.D., professor of neurobiology at the University of Pittsburgh School of Medicine.
Dr. Aizenman became interested in MIT as an offshoot to his primary area of research on the mechanisms of neuronal cell death. The first he heard of the chemical was when its name came up in a literature search for compounds with specific chemical properties that he thought would incite a particular cell death pathway he recently had identified. As it turned out, MIT activated a different, novel pathway, but Dr. Aizenman remained intrigued, in large part because of the considerable lack of scientific data about a compound that he came to realize was listed on numerous consumer product labels and was very widely used in industry.
Lisa Rossi | EurekAlert!
The Great Unknown: Risk-Taking Behavior in Adolescents
19.01.2017 | Max-Planck-Institut für Bildungsforschung
A sudden drop in outdoor temperature increases the risk of respiratory infections
11.01.2017 | University of Gothenburg
An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...
Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...
Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.
While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...
Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales
Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...
Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.
As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...
19.01.2017 | Event News
10.01.2017 | Event News
09.01.2017 | Event News
19.01.2017 | Earth Sciences
19.01.2017 | Life Sciences
19.01.2017 | Physics and Astronomy