An antimicrobial agent found in many shampoos and hand lotions and widely used in industrial settings inhibits the development of particular neuron structures that are essential for transmitting signals between cells, according to a University of Pittsburgh study presented today at Cell Biology 2004, the 44th annual meeting of the American Society for Cell Biology. The meeting is being held Dec. 4 – 8 at the Washington Convention Center.
Prolonged exposure to low levels of methylisothiazolinone (MIT) restricted growth of axons and dendrites of immature rat nerve cells in culture, apparently by disengaging the machinery of a key enzyme that is activated in response to cell-to-cell contact, and may have potentially damaging consequences to a developing nervous system, the researchers report. "While more research is needed to determine what effect MIT would have in rodent models, both at the cellular level and to a developing nervous system, our results thus far suggest there is potential that everyday exposure to the chemical could also be harmful to humans. I would be particularly concerned about occupational exposure in pregnant women and the possibility of risk to the fetus," said senior author Elias Aizenman, Ph.D., professor of neurobiology at the University of Pittsburgh School of Medicine.
Dr. Aizenman became interested in MIT as an offshoot to his primary area of research on the mechanisms of neuronal cell death. The first he heard of the chemical was when its name came up in a literature search for compounds with specific chemical properties that he thought would incite a particular cell death pathway he recently had identified. As it turned out, MIT activated a different, novel pathway, but Dr. Aizenman remained intrigued, in large part because of the considerable lack of scientific data about a compound that he came to realize was listed on numerous consumer product labels and was very widely used in industry.
Lisa Rossi | EurekAlert!
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Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
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Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
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In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
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