Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Nerve damage from alcoholism reversed after liver transplantation

02.12.2004


Organ damage that goes beyond the liver due to alcoholism is often seen as a barrier to liver transplantation, despite a lack of data on how a transplant affects these complications. A new study describes a patient with alcoholic liver disease complicated by peripheral neuropathy (nerve damage affecting the arms and legs) who underwent a liver transplant and regained almost normal muscle strength.



The results of this study appear in the December 2004 issue of Liver Transplantation, the official journal of the American Association for the Study of Liver Diseases (AASLD) and the International Liver Transplantation Society (ILTS). The journal is published on behalf of the societies by John Wiley & Sons, Inc. and is available online via Wiley InterScience.

Edward Gane, hepatologist at the New Zealand Liver Transplant Unit, and David Hutchinson, neurologist, report the case of a 50-year-old male patient with a 20-year history of drinking more than 100g of alcohol per day who had end-stage liver disease and weakness in both legs. When his condition continued to deteriorate after nine months of abstinence from alcohol, he was evaluated for a liver transplant. At this point, his neuropathy had progressed to the point where he could not rise from a chair without using his arms and had considerable difficulty climbing stairs. Liver transplants are usually not performed on patients with this type of complication because it is thought to be irreversible, although to date, very few studies have been conducted to verify this assertion.


Despite the patient’s poor prognosis and continued deterioration, he underwent a liver transplant in December 1999. Following the transplant, he noticed progressive recovery of strength in both legs. He was able to walk unaided after two months, and after six months he could rise from a chair and negotiate stairs normally. Neurological exams 12 months following the transplant showed significant improvement in motor function.

The authors maintain that the patient’s neuropathy was due not just to alcohol, but that liver failure played a major role in the disease. Symptoms of both conditions progressed simultaneously and the neuropathy had failed to improve despite nine months of abstinence, but did improve following the transplant.

"We initially considered the peripheral neuropathy in our patient to be a contraindication to OLT [orthotopic liver transplantation] due to its significant impact on his quality of life and the uncertainty about its prognosis following transplantation," the authors conclude. "Our experience with this patient suggests that peripheral neuropathy in a patient with alcoholic cirrhosis is reversible and should not constitute a contraindication to OLT, even when the neuropathy is disabling."

David Greenberg | EurekAlert!
Further information:
http://www.interscience.wiley.com/journal/livertransplantation
http://www.wiley.com

More articles from Studies and Analyses:

nachricht WAKE-UP provides new treatment option for stroke patients | International study led by UKE
17.05.2018 | Universitätsklinikum Hamburg-Eppendorf

nachricht First form of therapy for childhood dementia CLN2 developed
25.04.2018 | Universitätsklinikum Hamburg-Eppendorf

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

Im Focus: Entangled atoms shine in unison

A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.

The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

Designer cells: artificial enzyme can activate a gene switch

22.05.2018 | Life Sciences

PR of MCC: Carbon removal from atmosphere unavoidable for 1.5 degree target

22.05.2018 | Earth Sciences

Achema 2018: New camera system monitors distillation and helps save energy

22.05.2018 | Trade Fair News

VideoLinks
Science & Research
Overview of more VideoLinks >>>