Study presented in the November issue of the journal Arteriosclerosis, Thrombosis and Vascular Biology
Drinking Concord grape juice significantly increased HDL--the good cholesterol--and significantly lowered two markers of inflammation in people with stable coronary artery disease, according to results of a study presented in the November issue of the journal Arteriosclerosis, Thrombosis and Vascular Biology. "In addition to HDL levels increasing, we saw significant decreases in the production of superoxide, a free radical, and soluble CD40 ligand, an inflammatory marker about which there is growing interest," explains Jane E. Freedman, M.D., Associate Professor of Medicine and Pharmacology, Boston University School of Medicine and an author of the study. "Platelet release of soluble CD40 ligand is thought to contribute to the development of atherosclerosis and vascular inflammation.
We have seen in previous studies of healthy subjects that drinking grape juice decreases superoxide production and inhibits platelet aggregation, yet its impact on the inflammatory properties of platelets had not been previously studied. The soluble CD40 ligand information is new and particularly interesting, given the growing interest in the link between this inflammatory marker and cardiovascular disease."
Julie McQuain | EurekAlert!
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