The largest population study ever done into the risk of cancer in families that fulfil the criteria for BRCA1 and BRCA2 mutation testing has confirmed that breast and ovarian cancers are the major concerns for geneticists and doctors counselling families. It has also verified that families eligible for BRCA1/2 mutation testing are at increased risk of pancreatic, prostate and stomach cancers.
One important conclusion of the study was that, in families with at least one woman with breast cancer and another woman with ovarian cancer, most ovarian cancers are not attributable to BRCA1/2 mutations. Other, as yet unknown, non-BRCA1/2 related factors are likely to increase the risk of ovarian cancer in those families.
The study, published today (Monday 15 November) in Annals of Oncology, utilised the 2002 update of the Swedish Family-Cancer Database, which contains everyone born in Sweden after 1931 with their biological parents – a total of 10.2 million people. Nearly 948,000 families with at least three generations were classified according to the clinical criteria proposed by the German Consortium for Hereditary Breast and Ovarian Cancer for testing of BRCA1/2 mutations.
Prof Hemminki and Dr Lorenzo Bermejo concluded: "The main message from our study for families which fulfil the criteria for mutation testing is that their risk for cancers other than breast and ovarian cancer is only moderate. The message for those involved in clinical counselling is that most ovarian cancers in families eligible for mutation testing are not related to BRCA1/2 mutations."
 Risk of cancer at sites other than the breast in Swedish families eligible for BRCA1 or BRCA2 mutation testing. Annals of Oncology. Doi:10.1093/annonc/mdh474.
Obstructing the ‘inner eye’
07.07.2017 | Friedrich-Schiller-Universität Jena
Drone vs. truck deliveries: Which create less carbon pollution?
31.05.2017 | University of Washington
Physicists have developed a new technique that uses electrical voltages to control the electron spin on a chip. The newly-developed method provides protection from spin decay, meaning that the contained information can be maintained and transmitted over comparatively large distances, as has been demonstrated by a team from the University of Basel’s Department of Physics and the Swiss Nanoscience Institute. The results have been published in Physical Review X.
For several years, researchers have been trying to use the spin of an electron to store and transmit information. The spin of each electron is always coupled...
What is the mass of a proton? Scientists from Germany and Japan successfully did an important step towards the most exact knowledge of this fundamental constant. By means of precision measurements on a single proton, they could improve the precision by a factor of three and also correct the existing value.
To determine the mass of a single proton still more accurate – a group of physicists led by Klaus Blaum and Sven Sturm of the Max Planck Institute for Nuclear...
The research team of Prof. Dr. Oliver Einsle at the University of Freiburg's Institute of Biochemistry has long been exploring the functioning of nitrogenase....
A one trillion tonne iceberg - one of the biggest ever recorded -- has calved away from the Larsen C Ice Shelf in Antarctica, after a rift in the ice,...
Physics supports biology: Researchers from PTB have developed a model system to investigate friction phenomena with atomic precision
Friction: what you want from car brakes, otherwise rather a nuisance. In any case, it is useful to know as precisely as possible how friction phenomena arise –...
21.07.2017 | Event News
19.07.2017 | Event News
12.07.2017 | Event News
21.07.2017 | Earth Sciences
21.07.2017 | Power and Electrical Engineering
21.07.2017 | Physics and Astronomy