Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Obesity linked to another cancer - leukemia in older women

08.11.2004


University of Minnesota cancer researcher says shedding excess pounds may be key in preventing often fatal disease



A study from the University of Minnesota Cancer Center indicates that overweight and obesity could more than double an older woman’s risk of acute myelogenous leukemia (AML), an often fatal cancer of the bone marrow and blood. The results of the study are published in the November issue of Cancer Epidemiology, Biomarkers and Prevention journal.

Other studies have shown overweight and obesity are risk factors for colon, breast, kidney and endometrial cancers. This study, sponsored by the National Cancer Institute, examined the potential link between obesity and risk of leukemia. Over 14 years, the health of more than 37,000 older Iowa women was monitored; 200 of the women developed leukemia – 74 were diagnosed with AML and 88 with chronic lymphocytic leukemia (CLL). "We found that the risk for getting AML was 90 percent higher in overweight women age 55 and older who had a body mass index (BMI*) of 25-29," says Julie Ross, Ph.D., associate professor of pediatrics at the University of Minnesota Medical School. She also is an epidemiologist at the University of Minnesota Cancer Center and the lead researcher on this study. "In obese women age 55 and older and with a BMI of 30 or greater, the risk increased to as much as a 140 percent."


The study found little evidence of an association between overweight and obesity with CLL. AML is cancer that starts in the bone marrow in immature cells that normally should become white blood cells. Acute means the leukemia develops quickly. According to the American Cancer Society, about 33,400 new cases of leukemia will be diagnosed in the United Sates this year. About half of those cases will be acute leukemias. AML is the most common acute leukemia with about 11,900 patients diagnosed annually; 90 percent of them adults age 65 and older. About 8,870 people with AML will die this year. The 5-year survival rate for middle-aged people is about 12 percent and 3 percent for elderly adults.

While incidence rates for some adult leukemias, such as CLL and chronic myeloid leukemia, are declining in the United States, AML in people over age 65 has increased about 10 percent in the last 25 years. "The fact that survival rates for AML are extremely poor for older individuals makes identifying people who are at increased risk for this cancer of public health importance," Ross says. "Given that about 65 percent of adults in the United States are overweight or obese, the projection we can make from our study is that about 30 percent of AML in older adult women could be due to being overweight or obese."

This study is part of the Iowa Women’s Health Study. In 1986, over 40,000 women between the ages of 55 and 69 years completed a lifestyle and health questionnaire that included current height and weight. This study followed more than 37,000 of these women who, with the possible exception of skin cancer, were cancer-free at the beginning of the study. "The risk of AML was increased among women who reported being overweight or obese compared with women of normal weight," Ross says. We don’t know why higher BMI would be associated with leukemia, particularly AML. A possible explanation could be an alteration in hormones linked with obesity." She adds that while it can’t be said with research certainty, "it would seem that as with other cancers linked to obesity, reducing excess pounds and maintaining normal weight would be important in preventing AML."

Ross says a limitation of her study was that only postmenopausal, mostly white, women participated. She also says BMI was calculated using weight and height reported by each participant, which could be subject to some degree of imprecision. However, she notes, BMI is the standard for population-based studies.

Mary Lawson | EurekAlert!
Further information:
http://www.umn.edu

More articles from Studies and Analyses:

nachricht Multi-year study finds 'hotspots' of ammonia over world's major agricultural areas
17.03.2017 | University of Maryland

nachricht Diabetes Drug May Improve Bone Fat-induced Defects of Fracture Healing
17.03.2017 | Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A Challenging European Research Project to Develop New Tiny Microscopes

The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.

To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Researchers shoot for success with simulations of laser pulse-material interactions

29.03.2017 | Materials Sciences

Igniting a solar flare in the corona with lower-atmosphere kindling

29.03.2017 | Physics and Astronomy

As sea level rises, much of Honolulu and Waikiki vulnerable to groundwater inundation

29.03.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>