Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Obesity linked to another cancer - leukemia in older women

08.11.2004


University of Minnesota cancer researcher says shedding excess pounds may be key in preventing often fatal disease



A study from the University of Minnesota Cancer Center indicates that overweight and obesity could more than double an older woman’s risk of acute myelogenous leukemia (AML), an often fatal cancer of the bone marrow and blood. The results of the study are published in the November issue of Cancer Epidemiology, Biomarkers and Prevention journal.

Other studies have shown overweight and obesity are risk factors for colon, breast, kidney and endometrial cancers. This study, sponsored by the National Cancer Institute, examined the potential link between obesity and risk of leukemia. Over 14 years, the health of more than 37,000 older Iowa women was monitored; 200 of the women developed leukemia – 74 were diagnosed with AML and 88 with chronic lymphocytic leukemia (CLL). "We found that the risk for getting AML was 90 percent higher in overweight women age 55 and older who had a body mass index (BMI*) of 25-29," says Julie Ross, Ph.D., associate professor of pediatrics at the University of Minnesota Medical School. She also is an epidemiologist at the University of Minnesota Cancer Center and the lead researcher on this study. "In obese women age 55 and older and with a BMI of 30 or greater, the risk increased to as much as a 140 percent."


The study found little evidence of an association between overweight and obesity with CLL. AML is cancer that starts in the bone marrow in immature cells that normally should become white blood cells. Acute means the leukemia develops quickly. According to the American Cancer Society, about 33,400 new cases of leukemia will be diagnosed in the United Sates this year. About half of those cases will be acute leukemias. AML is the most common acute leukemia with about 11,900 patients diagnosed annually; 90 percent of them adults age 65 and older. About 8,870 people with AML will die this year. The 5-year survival rate for middle-aged people is about 12 percent and 3 percent for elderly adults.

While incidence rates for some adult leukemias, such as CLL and chronic myeloid leukemia, are declining in the United States, AML in people over age 65 has increased about 10 percent in the last 25 years. "The fact that survival rates for AML are extremely poor for older individuals makes identifying people who are at increased risk for this cancer of public health importance," Ross says. "Given that about 65 percent of adults in the United States are overweight or obese, the projection we can make from our study is that about 30 percent of AML in older adult women could be due to being overweight or obese."

This study is part of the Iowa Women’s Health Study. In 1986, over 40,000 women between the ages of 55 and 69 years completed a lifestyle and health questionnaire that included current height and weight. This study followed more than 37,000 of these women who, with the possible exception of skin cancer, were cancer-free at the beginning of the study. "The risk of AML was increased among women who reported being overweight or obese compared with women of normal weight," Ross says. We don’t know why higher BMI would be associated with leukemia, particularly AML. A possible explanation could be an alteration in hormones linked with obesity." She adds that while it can’t be said with research certainty, "it would seem that as with other cancers linked to obesity, reducing excess pounds and maintaining normal weight would be important in preventing AML."

Ross says a limitation of her study was that only postmenopausal, mostly white, women participated. She also says BMI was calculated using weight and height reported by each participant, which could be subject to some degree of imprecision. However, she notes, BMI is the standard for population-based studies.

Mary Lawson | EurekAlert!
Further information:
http://www.umn.edu

More articles from Studies and Analyses:

nachricht WAKE-UP provides new treatment option for stroke patients | International study led by UKE
17.05.2018 | Universitätsklinikum Hamburg-Eppendorf

nachricht First form of therapy for childhood dementia CLN2 developed
25.04.2018 | Universitätsklinikum Hamburg-Eppendorf

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

Im Focus: Entangled atoms shine in unison

A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.

The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

Designer cells: artificial enzyme can activate a gene switch

22.05.2018 | Life Sciences

PR of MCC: Carbon removal from atmosphere unavoidable for 1.5 degree target

22.05.2018 | Earth Sciences

Achema 2018: New camera system monitors distillation and helps save energy

22.05.2018 | Trade Fair News

VideoLinks
Science & Research
Overview of more VideoLinks >>>