Study shows weight-based REBETOL dosing in combination with PEG-INTRON significantly improves viral clearance in African-American patients with most-difficult-to-treat form of hepatitis C. WIN-R study provides important insights on improving hepatitis C treatment among African-Americans.
Twice as many African-American patients infected with the most difficult-to-treat form of chronic hepatitis C successfully cleared the virus when given a weight-based dose of REBETOL® (ribavirin, USP) rather than a flat dose, in combination with PEG-INTRON® (peginterferon alfa-2b), according to data presented at a Presidential Plenary session at the 55th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD) on Monday, November 1, at noon. The new findings, involving nearly 400 African-American patients from the large multicenter WIN-R study, are significant because African-Americans are known to have generally lower rates of response to hepatitis C therapy, and efforts are underway to improve outcomes for these patients.
"These results show that individualized therapy with weight-based ribavirin offers a significant advantage over a flat dose of ribavirin in the treatment of African-American patients chronically infected with hepatitis C genotype 1, the most difficult form of the virus to treat," said study principal investigator Ira M. Jacobson, M.D., Vincent Astor Professor of Clinical Medicine at Weill Cornell Medical College and chief of the division of gastroenterology and hepatology at NewYork-Presbyterian Hospital/Weill Cornell Medical Center in New York City. "Its also important to note that in this study the overall safety of weight-based ribavirin dosing was similar to that of the flat 800 mg dose," he said.
Jonathan Weil | EurekAlert!
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University of Maryland researchers contribute to historic detection of gravitational waves and light created by event
On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...
Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.
Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....
Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).
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Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.
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Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.
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