Study shows weight-based REBETOL dosing in combination with PEG-INTRON significantly improves viral clearance in African-American patients with most-difficult-to-treat form of hepatitis C. WIN-R study provides important insights on improving hepatitis C treatment among African-Americans.
Twice as many African-American patients infected with the most difficult-to-treat form of chronic hepatitis C successfully cleared the virus when given a weight-based dose of REBETOL® (ribavirin, USP) rather than a flat dose, in combination with PEG-INTRON® (peginterferon alfa-2b), according to data presented at a Presidential Plenary session at the 55th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD) on Monday, November 1, at noon. The new findings, involving nearly 400 African-American patients from the large multicenter WIN-R study, are significant because African-Americans are known to have generally lower rates of response to hepatitis C therapy, and efforts are underway to improve outcomes for these patients.
"These results show that individualized therapy with weight-based ribavirin offers a significant advantage over a flat dose of ribavirin in the treatment of African-American patients chronically infected with hepatitis C genotype 1, the most difficult form of the virus to treat," said study principal investigator Ira M. Jacobson, M.D., Vincent Astor Professor of Clinical Medicine at Weill Cornell Medical College and chief of the division of gastroenterology and hepatology at NewYork-Presbyterian Hospital/Weill Cornell Medical Center in New York City. "Its also important to note that in this study the overall safety of weight-based ribavirin dosing was similar to that of the flat 800 mg dose," he said.
Jonathan Weil | EurekAlert!
New study: How does Europe become a leading player for software and IT services?
03.04.2017 | Fraunhofer-Institut für System- und Innovationsforschung (ISI)
Reusable carbon nanotubes could be the water filter of the future, says RIT study
30.03.2017 | Rochester Institute of Technology
More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.
Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...
Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.
"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...
The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.
Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...
The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...
Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.
Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...
20.04.2017 | Event News
18.04.2017 | Event News
03.04.2017 | Event News
24.04.2017 | Life Sciences
24.04.2017 | Earth Sciences
24.04.2017 | Machine Engineering