Common prostate cancer therapy disrupts brains hippocampal memory system
Oregon Health & Science University researchers studying how testosterone deprivation affects verbal memory found that men undergoing the prostate cancer therapy forget things faster than their healthy counterparts. Scientists in the OHSU School of Medicines departments of Behavioral Neuroscience and Medicine, and the OHSU Cancer Institute, in a study presented Sunday to the Society for Neuroscience in San Diego, found that word retention drops sharply after only two minutes among men undergoing testosterone deprivation therapy.
However, initial learning of the words, or encoding, was the same for testosterone-deprived and healthy men, according to the study titled "Androgen ablation impairs hippocampal-dependent verbal memory processes." Men who have undergone testosterone deprivation "are able to encode these words well, and if I ask them immediately, they can recall them as easily as non-hormone-deprived men," said Joseph Bussiere, a graduate student in behavioral neuroscience and the studys lead author. "But after only two minutes, theres a marked drop-off. When you stretch the time between encoding and retrieval, thats where the problem lies."
Jonathan Modie | EurekAlert!
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